{"id":"W2013728473","doi":"10.2741/1905","title":"The promoter competition assay (PCA): a new approach to identify motifs involved in the transcriptional activity of reporter genes","year":2006,"lang":"en","type":"article","venue":"Frontiers in bioscience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Promoter; Reporter gene; Promoter activity; Gene; Transcription factor; Regulatory sequence; Biology; Computational biology; Sequence motif; Binding site; Transcription (linguistics); Transcriptional regulation; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003350355,0.002329509,0.002578672,0.002977534,0.0006690029,0.0009725338,0.001839907,0.001505944,0.001990279],"category_scores_gemma":[0.002977086,0.001126084,0.001445699,0.001463745,0.001647684,0.001040209,0.001475839,0.004388837,0.001698241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006400702,"about_ca_system_score_gemma":0.001142063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007035278,"about_ca_topic_score_gemma":0.001232749,"domain_scores_codex":[0.9955667,0.001864141,0.0002037114,0.0009005519,0.001161125,0.0003038115],"domain_scores_gemma":[0.9946311,0.003305945,0.0006313633,0.0004440319,0.0005474431,0.0004401221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403801,0.00007432801,0.0004443324,0.0002839841,0.00003296735,0.00004631366,0.0000414654,0.0001321744,0.9913632,0.0005902606,0.0001852624,0.006565395],"study_design_scores_gemma":[0.00004064834,0.0006190524,0.002177664,0.00002399517,0.00005047482,0.0007999829,0.00002717304,0.003471913,0.9873975,0.0004389673,0.004898826,0.00005386432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1132988,0.007827073,0.8718177,0.0004116602,0.0002889783,0.0007205086,0.001114202,0.001629064,0.002892059],"genre_scores_gemma":[0.2945783,0.007061706,0.6844014,0.0004880825,0.0002871854,0.002231518,0.002998057,0.0005637078,0.007390078],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003350355,"threshold_uncertainty_score":0.01771861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133777390331418,"score_gpt":0.2793647104680266,"score_spread":0.2580269365647124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}