{"id":"W2013770936","doi":"10.1016/j.nbd.2010.10.002","title":"Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice","year":2010,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute on Aging","keywords":"Choline acetyltransferase; Genetically modified mouse; Basal forebrain; Cholinergic neuron; Hippocampus; Amyloid precursor protein; Cholinergic; Senile plaques; Diagonal band of Broca; Pathology; Internal medicine; Alzheimer's disease; Endocrinology; Biology; Neuroscience; Transgene; Medicine; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161987,0.001074851,0.0005920155,0.002917611,0.0007438674,0.0007532121,0.0005018864,0.001188021,0.005617612],"category_scores_gemma":[0.0002530456,0.0005101482,0.0006717725,0.0006623145,0.001292778,0.0007923937,0.0004846252,0.001858913,0.0007634177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007851887,"about_ca_system_score_gemma":0.0005731324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003276947,"about_ca_topic_score_gemma":0.004413113,"domain_scores_codex":[0.999657,0.00002339339,0.00005270394,0.00009866865,0.00008439385,0.00008390783],"domain_scores_gemma":[0.9995108,0.00006273475,0.0001928401,0.00004042279,0.00004536292,0.0001479136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007401573,0.0001064788,0.0003322388,0.00003032343,0.00001843949,0.0008192161,0.00007857644,0.00005933683,0.9964039,0.0002891042,0.0001058889,0.001016359],"study_design_scores_gemma":[0.0002716977,0.0006085017,0.02344755,0.00003054784,0.0002025292,0.005271759,0.0004417089,0.001177898,0.9644706,0.0008604925,0.00316031,0.00005647547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920413,0.0007871384,0.001950748,0.0002718249,0.0001096294,0.00005269303,0.00262765,0.0002675651,0.001891339],"genre_scores_gemma":[0.9845254,0.001156442,0.002241444,0.0001954966,0.00004571617,0.0001529205,0.00183264,0.0002521858,0.009597699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005617612,"threshold_uncertainty_score":0.01879281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746058858597909,"score_gpt":0.292378066580366,"score_spread":0.2749174779943869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}