{"id":"W2013778612","doi":"10.1007/s10719-010-9287-0","title":"Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading","year":2010,"lang":"en","type":"article","venue":"Glycoconjugate Journal","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; Steacie Institute for Molecular Sciences","funders":"Beijing Advanced Innovation Center for Structural Biology, Tsinghua University","keywords":"Glycoconjugate; Chemistry; Teichoic acid; Reductive amination; Biochemistry; Glycosidic bond; Residue (chemistry); Lipid A; Oligosaccharide; Lipopolysaccharide; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006465913,0.0005524948,0.0006598948,0.0002764606,0.0007657188,0.0003681603,0.0007151567,0.0002462296,0.0005853119],"category_scores_gemma":[0.0005883852,0.0003620729,0.0002248358,0.0005471633,0.0003868124,0.000419878,0.0002167674,0.000995191,0.00007641231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008284228,"about_ca_system_score_gemma":0.001033939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004949198,"about_ca_topic_score_gemma":0.000985492,"domain_scores_codex":[0.9972454,0.0002510922,0.0009407817,0.000574641,0.0001240753,0.0008639793],"domain_scores_gemma":[0.9973935,0.0004956885,0.0005505966,0.0006242839,0.0005044982,0.0004313833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006655973,0.0001922327,0.007152316,0.00005790243,0.0003154278,0.00001165474,0.001202089,0.000720077,0.9875754,0.0008364738,0.0008622303,0.0004086605],"study_design_scores_gemma":[0.002186641,0.001011656,0.005721102,0.0005416463,0.0002896147,0.0003669131,0.001023212,0.00003062276,0.9747056,0.0006800733,0.01275287,0.000690083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946067,0.0002005701,0.0001308233,0.002207934,0.001040807,0.00123879,0.0001040022,0.0001002474,0.0003700716],"genre_scores_gemma":[0.9981067,0.00001300249,0.00058496,0.0003839032,0.0003786535,0.000247608,0.00005445039,0.00006346702,0.0001672418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01286977,"threshold_uncertainty_score":0.9998831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009046476244012535,"score_gpt":0.247852752452822,"score_spread":0.2388062762088094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}