{"id":"W2013782945","doi":"10.1182/blood-2003-06-2156","title":"The granzyme B–serglycin complex from cytotoxic granules requires dynamin for endocytosis","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Granzyme B; Granzyme; Cytotoxic T cell; Endocytic cycle; Endocytosis; Dynamin; Cell biology; Biology; Perforin; Exocytosis; Chemistry; Biochemistry; Receptor; Secretion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839729,0.0002038044,0.0002187761,0.0001311448,0.000159325,0.0005025803,0.0001744926,0.0003660582,0.0005951854],"category_scores_gemma":[0.0002439028,0.0001972213,0.0001905263,0.00007792935,0.0002595088,0.0004496929,0.0002692005,0.0003832894,0.0003577982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007512866,"about_ca_system_score_gemma":0.0002718579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005453169,"about_ca_topic_score_gemma":0.0005443876,"domain_scores_codex":[0.9998848,0.00001951289,0.00001288602,0.00001908033,0.00003953962,0.00002414246],"domain_scores_gemma":[0.9998648,0.00003027572,0.00003424529,0.00002439915,0.00001844672,0.00002776285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008642917,0.000006094907,0.0001626624,0.00001560216,0.00000231876,0.0000873652,0.000008178709,0.00008067486,0.9987264,0.0003746738,0.00001388107,0.0004357043],"study_design_scores_gemma":[0.00003639722,0.0001050357,0.003928878,0.000004687246,0.000006834435,0.0008050764,0.00002595238,0.002726106,0.990092,0.0002988943,0.001961296,0.000008813766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941361,0.0006162822,0.004201291,0.00007862897,0.00001606146,0.00001814037,0.00006359399,0.00004584446,0.0008239786],"genre_scores_gemma":[0.9955423,0.0003433587,0.002605649,0.00003284255,0.000004799492,0.00001219326,0.0001504591,0.00001923816,0.00128924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007512866,"threshold_uncertainty_score":0.005450964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383207049630236,"score_gpt":0.2299472691033019,"score_spread":0.2161151986069996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}