{"id":"W2013785611","doi":"10.1038/nature10805","title":"Enhancer decommissioning by LSD1 during embryonic stem cell differentiation","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":614,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; Medical Research Council; Canadian Institutes of Health Research","keywords":"Enhancer; Biology; Chromatin; Cell biology; Demethylase; Histone; Cellular differentiation; Chromatin remodeling; Reprogramming; Transcription factor; Genetics; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709125,0.0001516294,0.0002488474,0.0001870353,0.0002192375,0.0004768878,0.0002345335,0.0002177945,0.001564608],"category_scores_gemma":[0.0001474066,0.0002353132,0.0002439847,0.0001135603,0.0002498661,0.0003930349,0.0003817271,0.0006109273,0.0004079865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005329253,"about_ca_system_score_gemma":0.0003747129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180632,"about_ca_topic_score_gemma":0.002650382,"domain_scores_codex":[0.9999005,0.00000934995,0.000008810732,0.00002163265,0.00002337758,0.00003640062],"domain_scores_gemma":[0.9998927,0.000017553,0.00002579015,0.00001876604,0.00001387252,0.00003143009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872198,0.000008921174,0.0008843604,0.00003006607,0.000004905241,0.0001023905,0.00002798276,0.00006603364,0.9960425,0.0005950596,0.0000912883,0.001959203],"study_design_scores_gemma":[0.000008501102,0.00004233382,0.008616644,0.000004028248,0.000008285553,0.0001346808,0.00005342976,0.0003259513,0.9882237,0.0001340439,0.002445045,0.000003495083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891512,0.003367406,0.003803567,0.0002074351,0.00004679281,0.000009315349,0.000345954,0.0001506747,0.002917567],"genre_scores_gemma":[0.9946689,0.0003950413,0.0007303677,0.00006159092,0.000006707732,0.000007124964,0.0002993916,0.00002550445,0.003805276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564608,"threshold_uncertainty_score":0.005234182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004034507270765506,"score_gpt":0.2424457868316482,"score_spread":0.2384112795608827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}