{"id":"W2013788347","doi":"10.1021/bi800905v","title":"Impact of Retinal Disease-Associated RPE65 Mutations on Retinoid Isomerization","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute","keywords":"RPE65; Cis-trans-Isomerases; Biology; Mutant; Genetics; Mutation; Gene; Molecular biology; Isomerase; Peptidylprolyl isomerase; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784288,0.0004816949,0.0002041112,0.0003270613,0.0001977706,0.0002362002,0.00009616558,0.0003271829,0.001240013],"category_scores_gemma":[0.0003856904,0.0001115557,0.00027595,0.0001666874,0.0002921325,0.000135612,0.0002189849,0.0002160289,0.0002932322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001601063,"about_ca_system_score_gemma":0.000123217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005680126,"about_ca_topic_score_gemma":0.0004987172,"domain_scores_codex":[0.9998222,0.00003680308,0.00002921696,0.00004482569,0.00004224865,0.00002475342],"domain_scores_gemma":[0.9997956,0.00005768812,0.00007984112,0.00001765577,0.00001274436,0.00003648215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005160051,0.00006138916,0.03543058,0.00007543345,0.00007192811,0.009922696,0.0001423338,0.0005082506,0.9464057,0.0001890633,0.00006188545,0.006614721],"study_design_scores_gemma":[0.00008864896,0.001385011,0.3813502,0.00007424521,0.0004323585,0.0732192,0.0004814211,0.002460411,0.5354052,0.0004437337,0.004614112,0.00004548272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989679,0.0003033845,0.0002528665,0.00002261467,0.000003405518,0.000002716566,0.00006492241,0.00001423474,0.0003679073],"genre_scores_gemma":[0.9995359,0.00009455664,0.0001972525,0.00001051518,0.000001653398,0.000001180839,0.00005165952,0.000005729446,0.0001014808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001240013,"threshold_uncertainty_score":0.004148245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00929850386538106,"score_gpt":0.2526457505556686,"score_spread":0.2433472466902875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}