{"id":"W2013788347","doi":"10.1021/bi800905v","title":"Impact of Retinal Disease-Associated RPE65 Mutations on Retinoid Isomerization","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute","keywords":"RPE65; Cis-trans-Isomerases; Biology; Mutant; Genetics; Mutation; Gene; Molecular biology; Isomerase; Peptidylprolyl isomerase; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005358644,0.0001469053,0.0001112735,0.00002958737,0.00008817453,0.000005911885,0.0001240424,0.0001144023,0.00005895869],"category_scores_gemma":[0.0003232331,0.0001412248,0.000151226,0.000136902,0.0001240744,0.000002503059,0.0000327897,0.00005606849,0.00000913926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002941295,"about_ca_system_score_gemma":0.0002461302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007558331,"about_ca_topic_score_gemma":4.459361e-7,"domain_scores_codex":[0.9991723,0.00002281395,0.0001991673,0.0002651029,0.000167328,0.0001733005],"domain_scores_gemma":[0.9993982,0.000009149438,0.000132336,0.0002422476,0.0001110081,0.0001070833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002865412,0.0001961027,0.2426565,0.00002000913,0.00005860411,0.000005660531,0.00002967747,0.00006483838,0.7509406,0.000006874802,0.005632585,0.000102009],"study_design_scores_gemma":[0.0006062815,0.0002441174,0.5108021,0.00003181775,0.00001862986,0.000007388894,0.00002432077,0.00004215998,0.4877087,0.00003114251,0.0002385344,0.0002447728],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961253,0.0001406385,0.00004653461,0.00004947891,0.00004597251,0.00008823549,0.00005918078,0.00001593939,0.003428692],"genre_scores_gemma":[0.9960775,0.0001130398,0.00008474394,0.0000358782,0.00005670771,0.00001177434,0.001587748,0.00001694697,0.002015674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2681457,"threshold_uncertainty_score":0.5758981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00929850386538106,"score_gpt":0.2526457505556686,"score_spread":0.2433472466902875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}