{"id":"W2013789757","doi":"10.1021/bi000512q","title":"Mutational and Biochemical Analysis of Plasma Membrane Targeting Mediated by the Farnesylated, Polybasic Carboxy Terminus of K-ras4B","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Prenylation; Endoplasmic reticulum; ER retention; Cell biology; Chemistry; Vesicle; Green fluorescent protein; Vesicular transport protein; Biochemistry; Membrane; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641343,0.0004617588,0.0001729165,0.0001472935,0.0002825802,0.0002876299,0.0003097863,0.0004446036,0.001006911],"category_scores_gemma":[0.0002340586,0.0002156803,0.0002808154,0.0001796585,0.000340624,0.0002641396,0.0002508879,0.0006813236,0.000634262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005770972,"about_ca_system_score_gemma":0.000289707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150495,"about_ca_topic_score_gemma":0.00114351,"domain_scores_codex":[0.999801,0.00005647587,0.00002211652,0.00002769791,0.00006402075,0.00002871906],"domain_scores_gemma":[0.9997638,0.00005540028,0.00008185521,0.00003131032,0.00002813078,0.00003950197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003786992,0.00001046056,0.00004217963,0.00001740683,0.000002371631,0.00003171246,0.000007868841,0.00004157356,0.9995415,0.00009173584,0.00000530718,0.0001698985],"study_design_scores_gemma":[0.000009315767,0.00006925812,0.0009877955,0.000002779439,0.000007844333,0.000299355,0.00001471941,0.0005142433,0.9970414,0.00004464635,0.001004679,0.00000398559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934303,0.0006231171,0.004475792,0.0001158108,0.00001551982,0.00002618232,0.0003216793,0.00003738742,0.0009542948],"genre_scores_gemma":[0.9887336,0.0009106616,0.006750265,0.0000563488,0.000009153716,0.0000543716,0.001256541,0.00004625438,0.002182754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001150495,"threshold_uncertainty_score":0.004187107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003273878031776794,"score_gpt":0.1947189897488641,"score_spread":0.1914451117170873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}