{"id":"W2013795123","doi":"10.1111/j.1365-2982.2007.01016.x","title":"Downregulated hypothalamic 5‐HT<sub>3</sub> receptor expression and enhanced 5‐HT<sub>3</sub> receptor antagonist‐mediated improvement in fatigue‐like behaviour in cholestatic rats","year":2007,"lang":"en","type":"article","venue":"Neurogastroenterology & Motility","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tropisetron; Endocrinology; Internal medicine; 5-HT receptor; Serotonin; Receptor antagonist; Receptor; Cholestasis; Neurotransmitter; Antagonist; 5-HT3 receptor; Receptor expression; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490185,0.0004706619,0.000783739,0.0003540569,0.0001549466,0.0002564572,0.0001834563,0.0003984871,0.001955239],"category_scores_gemma":[0.000176008,0.0002685084,0.0004633869,0.0001556659,0.0005631907,0.000273454,0.0002102753,0.0008114954,0.0003654649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004708908,"about_ca_system_score_gemma":0.000340653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001668893,"about_ca_topic_score_gemma":0.003436113,"domain_scores_codex":[0.9998285,0.00002336752,0.00001990057,0.00003175592,0.00003457575,0.00006195725],"domain_scores_gemma":[0.9997037,0.00002673895,0.0001268489,0.00003526261,0.00002693325,0.00008047949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001254611,0.00005608343,0.000210851,0.00003457939,0.000008753467,0.00005888646,0.00001745263,0.00002204308,0.9975677,0.00002792729,0.00002386307,0.0007172465],"study_design_scores_gemma":[0.0002619857,0.005530337,0.03590088,0.0000142063,0.00007356402,0.0005681118,0.0001678267,0.001031276,0.955072,0.00008051352,0.001278221,0.0000210367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979041,0.0006260516,0.0006947467,0.00006290364,0.00001689941,0.00001929465,0.0002973494,0.00006281558,0.0003157875],"genre_scores_gemma":[0.9951549,0.0007020606,0.001294619,0.00009089919,0.00001440866,0.00008024528,0.0005354248,0.00002743962,0.002100144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955239,"threshold_uncertainty_score":0.006540954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03460905727703986,"score_gpt":0.344993197992687,"score_spread":0.3103841407156471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}