{"id":"W2013901561","doi":"10.1038/labinvest.3700178","title":"Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis","year":2004,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Lawson Health Research Institute; Canadian Diabetes Association","keywords":"MAPK/ERK pathway; Chelerythrine; Protein kinase C; Protein kinase A; Cell biology; Fibronectin; Downregulation and upregulation; Biology; Molecular biology; Chemistry; Endothelin 1; MEK inhibitor; Kinase; Extracellular matrix; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024842,0.0005337521,0.0001609141,0.0002371618,0.0002433709,0.0002752875,0.0002182131,0.0002947803,0.001458629],"category_scores_gemma":[0.0001920873,0.0001889684,0.0003207673,0.0001808137,0.000306014,0.0004416184,0.0002483414,0.0007031574,0.0002569401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005925182,"about_ca_system_score_gemma":0.000270564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301168,"about_ca_topic_score_gemma":0.002203149,"domain_scores_codex":[0.9998463,0.00003900546,0.00001348003,0.00001599978,0.00003035252,0.00005481307],"domain_scores_gemma":[0.9998749,0.00003570574,0.00001445115,0.00001615186,0.00001376351,0.00004503618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00205079,0.00008915431,0.0002144569,0.00006740582,0.000006352523,0.0001714768,0.00002259059,0.0001437719,0.9952982,0.0004043825,0.00004235316,0.001488997],"study_design_scores_gemma":[0.00008117632,0.0003221984,0.01759037,0.0000137891,0.00002457322,0.0003221474,0.00004747778,0.001333696,0.9789215,0.0001441402,0.001191529,0.000007374224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930677,0.00285709,0.001695253,0.0001625477,0.00006433237,0.00002432663,0.000299466,0.00002898993,0.001800261],"genre_scores_gemma":[0.9917636,0.00146404,0.00213675,0.00007780981,0.00003218341,0.00004629888,0.0005996616,0.000008411637,0.003871327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458629,"threshold_uncertainty_score":0.004879534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395737856000748,"score_gpt":0.2513675084827673,"score_spread":0.2374101299227599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}