{"id":"W2013953623","doi":"10.1038/ejhg.2012.67","title":"Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder","year":2012,"lang":"en","type":"article","venue":"European Journal of Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Linkage (software); Genetic linkage; Genetics; Genetic heterogeneity; Bipolar disorder; Schizophrenia (object-oriented programming); Delusion; Mania; Psychosis; Anhedonia; Phenotype; Biology; Population; Homogeneous; Computational biology; Psychology; Psychiatry; Medicine; Neuroscience; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00252542,0.001328616,0.0007919812,0.002791803,0.0006286303,0.001751329,0.0008498232,0.0009562343,0.002932451],"category_scores_gemma":[0.01235167,0.0002708887,0.001349075,0.002501114,0.001025775,0.001491303,0.002161773,0.001529843,0.0001795365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000659652,"about_ca_system_score_gemma":0.0006530352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00184266,"about_ca_topic_score_gemma":0.003722779,"domain_scores_codex":[0.9976003,0.001393895,0.0002456003,0.0002825602,0.0003404942,0.0001372312],"domain_scores_gemma":[0.9930528,0.003142223,0.002126131,0.0004962444,0.0005454325,0.0006372697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001381866,0.0002162422,0.9620935,0.0001711039,0.0008078227,0.0004651379,0.001123578,0.0007197937,0.005319573,0.003574542,0.0007514222,0.02337533],"study_design_scores_gemma":[0.0001526927,0.0006631803,0.9816991,0.00009534572,0.0005225723,0.00105451,0.001853427,0.003610021,0.0007307688,0.008294792,0.001249946,0.00007351252],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940574,0.0003549164,0.002548579,0.0004198569,0.00005890476,0.00003846522,0.000774735,0.00001937769,0.001727721],"genre_scores_gemma":[0.9934633,0.0001195694,0.005261862,0.00008397515,0.0000362031,0.00009237602,0.0005516443,0.00002485236,0.0003661336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002932451,"threshold_uncertainty_score":0.01335585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799592023697513,"score_gpt":0.2836805235091213,"score_spread":0.2656846032721462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}