{"id":"W2013956662","doi":"10.1055/s-2009-1216399","title":"Antimalarial Agents from Plants: Neocryptolepine Derivatives and Standardised Extracts from Traditional Medicine","year":2009,"lang":"en","type":"article","venue":"Planta Medica","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Agricultural Research Service; National Center for Complementary and Alternative Medicine; National Oceanic and Atmospheric Administration; U.S. Food and Drug Administration; National Science Foundation of Sri Lanka; University of Colombo; University Grants Commission; Tata Trusts; International Science Council; Kurukshetra University; China Academy of Traditional Chinese Medicine; Western Carolina University; University of British Columbia; Deutsche Krebshilfe; National Natural Science Foundation of China; National Institutes of Health; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Hong Kong Polytechnic University; Chinese Academy of Sciences; Wake Forest University","keywords":"Plasmodium berghei; Traditional medicine; Antimalarial Agent; In vivo; Bark (sound); Malaria; Rubiaceae; Pharmacology; Quinoline; Biology; Chemistry; Medicine; Chloroquine; Botany; Biotechnology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169337,0.0001976828,0.0002889886,0.0000399725,0.0001043179,0.00002287688,0.0001641224,0.0001508903,0.0004636252],"category_scores_gemma":[0.0002000821,0.0001581992,0.00004078469,0.00003168478,0.0001579197,0.00001070185,0.00003179437,0.0001158276,0.000004667542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008321178,"about_ca_system_score_gemma":0.00004976012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002015139,"about_ca_topic_score_gemma":0.0000387382,"domain_scores_codex":[0.9986707,0.00008327648,0.0002306446,0.0004362485,0.0003731199,0.0002060267],"domain_scores_gemma":[0.9993688,0.0001176197,0.00009798893,0.000207908,0.00002024955,0.0001874316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001340715,0.0005509511,0.007346882,0.00000471957,0.0003509438,0.0001191327,0.0005892459,4.282954e-7,0.9132036,0.00002588821,0.03266753,0.04379995],"study_design_scores_gemma":[0.004765,0.001427403,0.8571535,0.0001606775,0.0001156897,0.00003549885,0.0005811426,0.00006440917,0.1040372,0.001066277,0.03016833,0.0004248797],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935923,0.0007563746,0.0007019637,0.002243899,0.0002461718,0.000154228,0.001128397,0.00001893503,0.001157784],"genre_scores_gemma":[0.9940565,0.0006205757,0.0005857871,0.0008452868,0.001534342,0.000004071571,0.002325126,0.00001039051,0.00001793531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8498066,"threshold_uncertainty_score":0.6451177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475117125923671,"score_gpt":0.2545073932400186,"score_spread":0.2297562219807819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}