{"id":"W2013956662","doi":"10.1055/s-2009-1216399","title":"Antimalarial Agents from Plants: Neocryptolepine Derivatives and Standardised Extracts from Traditional Medicine","year":2009,"lang":"en","type":"article","venue":"Planta Medica","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Agricultural Research Service; National Center for Complementary and Alternative Medicine; National Oceanic and Atmospheric Administration; U.S. Food and Drug Administration; National Science Foundation of Sri Lanka; University of Colombo; University Grants Commission; Tata Trusts; International Science Council; Kurukshetra University; China Academy of Traditional Chinese Medicine; Western Carolina University; University of British Columbia; Deutsche Krebshilfe; National Natural Science Foundation of China; National Institutes of Health; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Hong Kong Polytechnic University; Chinese Academy of Sciences; Wake Forest University","keywords":"Plasmodium berghei; Traditional medicine; Antimalarial Agent; In vivo; Bark (sound); Malaria; Rubiaceae; Pharmacology; Quinoline; Biology; Chemistry; Medicine; Chloroquine; Botany; Biotechnology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088333,0.0003553868,0.0002301503,0.0005166846,0.0001128428,0.0001769099,0.0001868362,0.0002523195,0.001053071],"category_scores_gemma":[0.0001145719,0.00009525882,0.0001873805,0.0003032777,0.0001571312,0.0002417548,0.0001637721,0.0004188917,0.0003585291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734717,"about_ca_system_score_gemma":0.0001403315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004814955,"about_ca_topic_score_gemma":0.001247375,"domain_scores_codex":[0.9999269,0.0000117361,0.000006072881,0.00001675892,0.00002911102,0.000009446458],"domain_scores_gemma":[0.9999478,0.000008290817,0.00001518297,0.000005472469,0.00001501041,0.000008323838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007377732,0.00003508996,0.0001811378,0.0003609808,0.000007298712,0.00008977402,0.00002061253,0.00008195976,0.9869364,0.0001136638,0.00005468341,0.01204463],"study_design_scores_gemma":[0.00004882158,0.001136581,0.008406059,0.00007976378,0.00006738939,0.001122463,0.0000369553,0.0005268885,0.9687486,0.0001370348,0.01967225,0.00001722161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8667476,0.1000717,0.01675636,0.0005259133,0.0001041733,0.0005310206,0.001251679,0.000292671,0.01371903],"genre_scores_gemma":[0.9462633,0.03121344,0.01579166,0.0003322455,0.00008231349,0.0001125427,0.001081817,0.0000229872,0.005099739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053071,"threshold_uncertainty_score":0.003522873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475117125923671,"score_gpt":0.2545073932400186,"score_spread":0.2297562219807819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}