{"id":"W2013973620","doi":"10.1083/jcb.200205027","title":"A neurotoxic peripherin splice variant in a mouse model of ALS","year":2003,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"Wellcome Trust","keywords":"Peripherin; Biology; Transgene; Genetically modified mouse; Amyotrophic lateral sclerosis; Motor neuron; Gene isoform; Cell biology; Molecular biology; Alternative splicing; RNA splicing; Genetics; Neuroscience; Pathology; Gene; Spinal cord; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003718387,0.0008805995,0.0004325449,0.001173064,0.0004229197,0.000417068,0.0004329601,0.001213443,0.002244446],"category_scores_gemma":[0.0001954875,0.0004562791,0.0003426103,0.0002761237,0.0006180239,0.0005045069,0.000362847,0.001216561,0.0006354547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003824051,"about_ca_system_score_gemma":0.0002106124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003693818,"about_ca_topic_score_gemma":0.0007356296,"domain_scores_codex":[0.9996974,0.00005849094,0.00004694239,0.00008726602,0.00006750518,0.0000423708],"domain_scores_gemma":[0.9996433,0.00005234073,0.0001186127,0.00004710623,0.00002605861,0.0001125124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00022461,0.0001297366,0.0001455435,0.00004016714,0.000009356367,0.0004128109,0.00002928172,0.00006143418,0.9978831,0.0002652222,0.00006188425,0.0007367101],"study_design_scores_gemma":[0.0003720582,0.00354101,0.00795991,0.00007418206,0.0001171243,0.006697165,0.000129725,0.0024081,0.971447,0.0007444048,0.006478965,0.00003036877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932867,0.001081553,0.002872844,0.0002763271,0.00006454623,0.00009268643,0.0005536962,0.0002270921,0.001544624],"genre_scores_gemma":[0.9800961,0.001660251,0.006310679,0.0001921465,0.00003392219,0.0002538123,0.001386299,0.00009826884,0.00996864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244446,"threshold_uncertainty_score":0.007508397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04177772366491592,"score_gpt":0.3002890507344084,"score_spread":0.2585113270694925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}