{"id":"W2013978706","doi":"10.1074/jbc.m110.126789","title":"Oxidative and Nitrosative Modifications of Tropoelastin Prevent Elastic Fiber Assembly in Vitro","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute","keywords":"Tropoelastin; Elastin; Elastic fiber; Desmosine; Biophysics; Chemistry; Elastic recoil; Hypochlorous acid; Peroxynitrite; Fibulin; Oxidative stress; In vitro; Stress fiber; Biochemistry; Extracellular matrix; Cell biology; Materials science; Superoxide; Biology; Amino acid; Signal transduction; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711329,0.0003560917,0.0002027229,0.0001332449,0.0001370075,0.0001603134,0.0002256563,0.0002151573,0.001230146],"category_scores_gemma":[0.0002554045,0.0001445846,0.0002759836,0.0001106961,0.0001770896,0.0001581767,0.0001765631,0.0003992409,0.0002908294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379064,"about_ca_system_score_gemma":0.0001934403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081448,"about_ca_topic_score_gemma":0.001716375,"domain_scores_codex":[0.9997572,0.00005185445,0.00002481506,0.00005054755,0.00004860045,0.00006698131],"domain_scores_gemma":[0.9997663,0.00007969659,0.00005209522,0.00003353491,0.00003433171,0.00003410739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001541942,0.00005881259,0.0001153013,0.00003548344,0.000007486766,0.00003177359,0.00001728502,0.00004155169,0.9988717,0.00003269517,0.00003248984,0.0006011882],"study_design_scores_gemma":[0.00001466314,0.0004658552,0.00322801,0.000008624389,0.0000154725,0.0001013651,0.00002092372,0.0007168226,0.9934024,0.00004062632,0.001981562,0.000003601955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896474,0.003442125,0.003553233,0.00009288616,0.00009176304,0.00006087918,0.0003959148,0.00004384921,0.00267193],"genre_scores_gemma":[0.9878659,0.001878445,0.004453407,0.0001351715,0.00002705887,0.00005654482,0.001910211,0.00002864473,0.003644651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230146,"threshold_uncertainty_score":0.004115283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126936890057493,"score_gpt":0.3022428183152413,"score_spread":0.2809734494146664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}