{"id":"W2014050718","doi":"10.1038/leu.2008.175","title":"BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells","year":2008,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Lymphoma Research Foundation","keywords":"Bortezomib; Chronic lymphocytic leukemia; Proteasome inhibitor; MAPK/ERK pathway; Kinase; Biology; Cancer research; Phosphorylation; Apoptosis; Leukemia; Pharmacology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007096534,0.0005048888,0.0006995095,0.000384963,0.000315415,0.00008293988,0.000212199,0.0002693235,0.00007675313],"category_scores_gemma":[0.0003581581,0.000367259,0.0001030863,0.001046945,0.0003537023,0.0003249564,0.0001882008,0.000680356,0.0003293393],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1680943,"about_ca_system_score_gemma":0.02966072,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007144521,"about_ca_topic_score_gemma":0.001166201,"domain_scores_codex":[0.9963611,0.000252273,0.0006333671,0.0009552087,0.0008825375,0.000915453],"domain_scores_gemma":[0.9976622,0.0006868942,0.0001939905,0.0008119546,0.000238485,0.0004064716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.006069897,0.0001575701,0.001251231,0.001370461,0.0006117885,0.006416228,0.007964662,0.4231298,0.5255128,0.0002772426,0.008660029,0.01857827],"study_design_scores_gemma":[0.01352501,0.0007624038,0.008776033,0.000963587,0.0001850825,0.002850932,0.0003772245,0.7145397,0.2554279,0.00002704887,0.001953048,0.0006119665],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950846,0.001301033,0.0003057431,0.000326339,0.0002429049,0.001595411,0.00001115092,0.0001399169,0.0009928776],"genre_scores_gemma":[0.9960212,0.0006476984,0.0002912377,0.0003531321,0.0004048475,0.0001433461,0.00003740352,0.00009479217,0.002006395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2914099,"threshold_uncertainty_score":0.9998779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208147057537915,"score_gpt":0.2719792681412461,"score_spread":0.2511645623874546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}