{"id":"W2014070591","doi":"10.1128/aac.01403-07","title":"In Vitro Selection and Characterization of Ceftobiprole-Resistant Methicillin-Resistant <i>Staphylococcus aureus</i>","year":2008,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Johnson and Johnson Pharmaceutical Research and Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Howard Hughes Medical Institute","keywords":"Penicillin binding proteins; SCCmec; Microbiology; Plasmid; Staphylococcus aureus; Mutant; Biology; Cephalosporin; Penicillin; Gene; Antibiotics; Methicillin-resistant Staphylococcus aureus; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001995304,0.0004177853,0.0003610825,0.0001718353,0.0001251289,0.0003565617,0.0003058276,0.0002285827,0.0006472514],"category_scores_gemma":[0.000394605,0.0001665529,0.0002800005,0.0002223593,0.0001057078,0.0001132838,0.0002429244,0.0004072147,0.0009103171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206983,"about_ca_system_score_gemma":0.0001250273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559531,"about_ca_topic_score_gemma":0.001340157,"domain_scores_codex":[0.999603,0.0001003596,0.00005769279,0.00005801058,0.0001235498,0.00005744984],"domain_scores_gemma":[0.9997153,0.00008884182,0.00005848373,0.00005079207,0.00004949024,0.00003713098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003511416,0.00003133225,0.0003376683,0.00001687423,0.000002835871,0.00003943644,0.00001470354,0.00004946052,0.9987509,0.00002216255,0.00003096477,0.0006684529],"study_design_scores_gemma":[0.000004943914,0.0002133719,0.004614445,0.000004982804,0.00001195926,0.0003951934,0.00002479253,0.0008236307,0.9921184,0.00000968253,0.001772356,0.000006253116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881446,0.001144358,0.00615373,0.0001130226,0.00004479885,0.0001038701,0.001769805,0.0001381997,0.002387575],"genre_scores_gemma":[0.9740924,0.001101655,0.01283245,0.00009787453,0.00002682583,0.0001058405,0.006729824,0.0001293131,0.004883806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559531,"threshold_uncertainty_score":0.003100932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467827108012025,"score_gpt":0.2550848319690389,"score_spread":0.2404065608889186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}