{"id":"W2014070591","doi":"10.1128/aac.01403-07","title":"In Vitro Selection and Characterization of Ceftobiprole-Resistant Methicillin-Resistant <i>Staphylococcus aureus</i>","year":2008,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Johnson and Johnson Pharmaceutical Research and Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; Howard Hughes Medical Institute","keywords":"Penicillin binding proteins; SCCmec; Microbiology; Plasmid; Staphylococcus aureus; Mutant; Biology; Cephalosporin; Penicillin; Gene; Antibiotics; Methicillin-resistant Staphylococcus aureus; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001980122,0.0003215004,0.0006589178,0.0002524951,0.0001583461,0.00002323938,0.00008984149,0.0002302667,0.00005637664],"category_scores_gemma":[0.00001995551,0.0002971598,0.0001107223,0.0004215851,0.0003026195,0.0001749361,0.00003698749,0.0002624903,0.000002544667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006637365,"about_ca_system_score_gemma":0.0001116426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001996106,"about_ca_topic_score_gemma":0.0000309151,"domain_scores_codex":[0.9982103,0.00006014992,0.0006042502,0.0005012652,0.0002377112,0.0003863999],"domain_scores_gemma":[0.9991963,0.00003595421,0.0002637109,0.0002177136,0.0001590528,0.0001272518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003394165,0.0003082902,0.01048949,0.0002319235,0.0000777091,0.00004558152,0.0006230007,0.000001029003,0.9826799,0.00003667671,0.001211538,0.0009007046],"study_design_scores_gemma":[0.003340865,0.0002255735,0.14049,0.0001913528,0.0000488962,0.00002371305,0.00003334914,0.00009059755,0.8380259,0.00002341915,0.01720935,0.0002970039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963769,0.00008013601,0.0002134105,0.002318512,0.00008759367,0.0006549695,0.00007908987,0.00003889209,0.0001505413],"genre_scores_gemma":[0.9898595,0.003244889,0.00107172,0.005182257,0.0001067642,0.00001112664,0.00005390817,0.00005463919,0.0004152264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.144654,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467827108012025,"score_gpt":0.2550848319690389,"score_spread":0.2404065608889186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}