{"id":"W2014078988","doi":"10.1021/jm0002836","title":"Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Potentiator; Chemistry; Propanoic acid; AMPA receptor; Stereochemistry; Receptor; Ionotropic effect; Pharmacology; Glutamate receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002151302,0.000545489,0.0002639123,0.0002648333,0.0001448468,0.0002761674,0.0002923323,0.0003173433,0.003828453],"category_scores_gemma":[0.0001241454,0.0001783932,0.0001887055,0.0001378952,0.0001274053,0.0004313187,0.0003042519,0.0004152154,0.001993257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923027,"about_ca_system_score_gemma":0.0002061497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000274584,"about_ca_topic_score_gemma":0.001111089,"domain_scores_codex":[0.9998857,0.00001897837,0.000008886243,0.00001066345,0.0000504608,0.00002532426],"domain_scores_gemma":[0.9999568,0.000003888769,0.00001140898,0.000003100119,0.000009589651,0.00001524129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005138514,0.0001778387,0.00009305297,0.0002203126,0.00002274412,0.0001506464,0.0000330643,0.0002091539,0.967682,0.0006582661,0.001907953,0.02833117],"study_design_scores_gemma":[0.0007177991,0.003949185,0.00266068,0.00005569531,0.0001009161,0.0007854852,0.00004604673,0.00159774,0.9257132,0.0003236456,0.06401629,0.00003333842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8646061,0.07428028,0.01109972,0.001531937,0.001005097,0.0005386756,0.001160396,0.0005706763,0.04520717],"genre_scores_gemma":[0.8788412,0.0575631,0.008340458,0.0007420386,0.0003404273,0.0003076903,0.001704538,0.00007283139,0.05208781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003828453,"threshold_uncertainty_score":0.01280749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02743142936662401,"score_gpt":0.3092107103783193,"score_spread":0.2817792810116952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}