{"id":"W2014083595","doi":"10.1364/oe.21.001189","title":"Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC)","year":2013,"lang":"en","type":"article","venue":"Optics Express","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Division of Chemistry; Division of Materials Research; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Materials Research Science and Engineering Center, Harvard University; McGill University; National Science Foundation; National Institutes of Health; Harvard University","keywords":"Total internal reflection fluorescence microscope; Fluorophore; Microscopy; Molecular motor; Fluorescence; Fluorescence microscope; Fluorescence-lifetime imaging microscopy; Biophysics; Protein filament; Optics; Materials science; Nanotechnology; Physics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004398775,0.0003385484,0.0001851788,0.0002227302,0.0001445598,0.0003810018,0.0003984607,0.0002998941,0.0002978409],"category_scores_gemma":[0.0003001532,0.0002174652,0.0001571853,0.0001970583,0.0006026619,0.0003166062,0.0003173072,0.0004259451,0.000118504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005332073,"about_ca_system_score_gemma":0.0004220283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002202856,"about_ca_topic_score_gemma":0.003893715,"domain_scores_codex":[0.9998217,0.00002964127,0.00000714923,0.00003770558,0.00005954417,0.00004424141],"domain_scores_gemma":[0.9997181,0.00008769105,0.00008422861,0.00002553779,0.00004765002,0.0000367126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002957148,0.000007269618,0.0001685274,0.000016739,0.000001755691,0.00001930523,0.00003108694,0.0001895258,0.9975973,0.0002348718,0.00002045589,0.00168345],"study_design_scores_gemma":[0.000007991058,0.00006839291,0.0008431053,0.000002761572,0.0000039637,0.00005699985,0.00002299504,0.004938848,0.9935806,0.00004934874,0.0004178136,0.000007322014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480752,0.0005541021,0.04966252,0.0001174095,0.000009055628,0.0000365897,0.00005101134,0.0001249396,0.001369186],"genre_scores_gemma":[0.9166601,0.0007847815,0.08058957,0.00008214042,0.00001094672,0.00006221827,0.00009615496,0.00004353945,0.001670575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002202856,"threshold_uncertainty_score":0.004380107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03511570812685717,"score_gpt":0.290330765893146,"score_spread":0.2552150577662889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}