{"id":"W2014104258","doi":"10.1016/j.bbrc.2004.10.070","title":"Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein","year":2004,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Thapsigargin; Endoplasmic reticulum; SERCA; Curcumin; Mutant; Chemistry; Cell biology; Chaperone (clinical); Glycoprotein; Biochemistry; P-glycoprotein; Biology; ATPase; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097483,0.0003240229,0.0003740203,0.0001788094,0.0002463646,0.0003706626,0.000186716,0.0004032439,0.002385665],"category_scores_gemma":[0.0005006183,0.0001836497,0.0003817125,0.0001196102,0.0004402433,0.0004635131,0.000232244,0.0009106529,0.0007857019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005492493,"about_ca_system_score_gemma":0.0007084166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002431994,"about_ca_topic_score_gemma":0.004654299,"domain_scores_codex":[0.9997618,0.00004136314,0.00002238061,0.0000306468,0.0000560284,0.0000878014],"domain_scores_gemma":[0.9994973,0.0001783673,0.00007086907,0.000101481,0.00005034359,0.0001015652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006011301,0.00004461601,0.00009336996,0.00003553162,0.000007653133,0.0001429244,0.00002230832,0.00003296175,0.9980986,0.000141067,0.0001988791,0.0005810679],"study_design_scores_gemma":[0.00004940848,0.000338458,0.002015726,0.000005359821,0.00002069663,0.0004353588,0.00006332013,0.0002818349,0.9928102,0.00007712137,0.003895496,0.000007078724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915181,0.00190004,0.00155747,0.0005857528,0.0002032504,0.00005062121,0.0005937754,0.0001582632,0.003432656],"genre_scores_gemma":[0.9910918,0.0008242655,0.001266199,0.0001111894,0.0000267948,0.00004995603,0.0009154209,0.00006438488,0.005649992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002431994,"threshold_uncertainty_score":0.007980883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05713293275151485,"score_gpt":0.3514042652760655,"score_spread":0.2942713325245506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}