{"id":"W2014107536","doi":"10.1016/j.fct.2012.12.063","title":"Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products","year":2013,"lang":"en","type":"review","venue":"Food and Chemical Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; McGill University; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Acetaminophen; Liver injury; Thioacetamide; Pharmacology; Lipid peroxidation; Carbon tetrachloride; Drug; Detoxification (alternative medicine); Programmed cell death; Medicine; Apoptosis; Chemistry; Oxidative stress; Biochemistry; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003712476,0.001109449,0.001453536,0.002761528,0.0001880282,0.0005753716,0.0006867442,0.0006402111,0.002660007],"category_scores_gemma":[0.0002413524,0.000234935,0.0006694261,0.001741611,0.000284038,0.0006557857,0.0004354423,0.001091374,0.001183811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512671,"about_ca_system_score_gemma":0.000648525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115646,"about_ca_topic_score_gemma":0.00291718,"domain_scores_codex":[0.9998789,0.00001566432,0.00001539578,0.00002049501,0.00005755592,0.00001195705],"domain_scores_gemma":[0.9998502,0.00004926695,0.00003481082,0.000007419013,0.00004465741,0.00001358495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002329623,0.0003213118,0.0002510893,0.02421296,0.0001656459,0.0002768945,0.00004985701,0.0006341311,0.03869653,0.002112102,0.0103281,0.9227183],"study_design_scores_gemma":[0.00009477232,0.0006682526,0.002335426,0.00366776,0.0006889323,0.001785402,0.0001099737,0.0003369501,0.01987025,0.002051647,0.9683216,0.00006893644],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009881621,0.9953382,0.0009514503,0.0001177396,0.0001179155,0.00003808408,0.0001490664,0.00002401772,0.002275254],"genre_scores_gemma":[0.003467682,0.9936598,0.001053492,0.0001102687,0.00005391357,0.0000296887,0.0001553406,0.000003464797,0.001466325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002761528,"threshold_uncertainty_score":0.008898616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3323465478066591,"score_gpt":0.4683297948912185,"score_spread":0.1359832470845594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}