{"id":"W2014133798","doi":"10.1242/dev.046987","title":"Oriented cell motility and division underlie early limb bud morphogenesis","year":2010,"lang":"en","type":"article","venue":"Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Biology; Mesoderm; Limb bud; Limb development; Lateral plate mesoderm; Ectoderm; Morphogenesis; Zone of polarizing activity; Anatomy; Apical ectodermal ridge; Cell biology; Intermediate mesoderm; Organogenesis; Gastrulation; Embryo; Embryogenesis; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881846,0.0001487321,0.00009904188,0.00003686299,0.000158753,0.00001471884,0.00009200558,0.0001935417,0.00003528012],"category_scores_gemma":[0.00001487832,0.000136311,0.00002750902,0.00006278723,0.00007521295,0.000003060234,0.0001647139,0.00008042678,0.00003568881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001143846,"about_ca_system_score_gemma":0.00009052484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005802476,"about_ca_topic_score_gemma":0.00004946412,"domain_scores_codex":[0.9991226,0.00002525928,0.000186429,0.0003658697,0.00009942769,0.0002004657],"domain_scores_gemma":[0.9996079,0.000007702069,0.00005151683,0.0001851132,0.00005156763,0.00009615803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003975507,0.00006834046,0.1909109,0.00001139939,0.00002625425,0.000001453281,0.0001028711,0.000001747101,0.7840251,0.00003032681,0.0001650687,0.02461674],"study_design_scores_gemma":[0.0002035695,0.00004183603,0.5393896,0.00000191321,0.000002743555,0.000003634297,0.00001214783,0.000004032846,0.4415407,0.00001649837,0.01868068,0.0001026784],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977319,0.000126024,0.000837016,0.00005751941,0.0002751004,0.000142803,0.000004407223,0.0000170612,0.0008081811],"genre_scores_gemma":[0.9921954,0.00002422801,0.006110797,0.0001010112,0.00003753999,0.00001692372,0.0001947569,0.00001158611,0.001307751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3484786,"threshold_uncertainty_score":0.5558602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003781793518088909,"score_gpt":0.1995255645205062,"score_spread":0.1957437710024173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}