{"id":"W2014137103","doi":"10.1038/cdd.2014.149","title":"REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury","year":2014,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Axotomy; PI3K/AKT/mTOR pathway; Retinal ganglion cell; Dendrite (mathematics); Downregulation and upregulation; Cell biology; Neuroscience; Gene knockdown; Small interfering RNA; Soma; Programmed cell death; Biology; Chemistry; Optic nerve; Apoptosis; Signal transduction; Regeneration (biology); Cell culture; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008519113,0.00009433568,0.00008568654,0.00004198211,0.00005373528,0.00001638314,0.00002713012,0.0001507013,0.00001430775],"category_scores_gemma":[0.00005965079,0.00008977072,0.00002862889,0.00004463763,0.00001585849,0.000008843575,0.00002066592,0.00005330482,0.000003108341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005553699,"about_ca_system_score_gemma":0.00001494366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009921348,"about_ca_topic_score_gemma":0.000003780929,"domain_scores_codex":[0.999412,0.00004172985,0.0001615257,0.000181405,0.0001014853,0.0001018816],"domain_scores_gemma":[0.9996963,0.000009520732,0.0001123156,0.00007723811,0.00005599661,0.00004865324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008077572,0.00005842546,0.01744201,0.00003497364,0.000007088281,3.84741e-8,0.00002535811,1.67528e-7,0.9796975,0.00003207495,0.0006022778,0.002019326],"study_design_scores_gemma":[0.0005752174,0.0002895005,0.1189772,0.00001519174,0.00001684907,5.568466e-7,0.00001970045,0.0002587766,0.8783444,0.0002228309,0.001144562,0.0001351665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971732,0.0001080391,0.001574927,0.00003717199,0.00009910487,0.0001140031,0.00001041964,0.000008920852,0.0008742057],"genre_scores_gemma":[0.9981325,0.0001369415,0.0001143801,0.00004204291,0.00005154315,0.00000873507,0.001326523,0.000008315934,0.0001789618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015352,"threshold_uncertainty_score":0.3660744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00626827785474302,"score_gpt":0.2081276572917818,"score_spread":0.2018593794370387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}