{"id":"W2014137103","doi":"10.1038/cdd.2014.149","title":"REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury","year":2014,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Axotomy; PI3K/AKT/mTOR pathway; Retinal ganglion cell; Dendrite (mathematics); Downregulation and upregulation; Cell biology; Neuroscience; Gene knockdown; Small interfering RNA; Soma; Programmed cell death; Biology; Chemistry; Optic nerve; Apoptosis; Signal transduction; Regeneration (biology); Cell culture; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009243761,0.0003750896,0.0002730869,0.0002351995,0.0001912004,0.0002849023,0.0001763188,0.0002486996,0.0009099048],"category_scores_gemma":[0.00005498048,0.0001525027,0.0002631465,0.0001342416,0.0002728431,0.0001559629,0.0002258485,0.0005358952,0.0002296551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003976031,"about_ca_system_score_gemma":0.000196912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004911195,"about_ca_topic_score_gemma":0.001281671,"domain_scores_codex":[0.9998976,0.00001069284,0.000009796785,0.00002967576,0.00002765452,0.00002454955],"domain_scores_gemma":[0.9999485,0.000006631501,0.00001620477,0.000006290206,0.000004776682,0.00001753755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006839631,0.00001439939,0.00009261949,0.00003108821,0.00000406928,0.00004423172,0.000005606681,0.00003943016,0.9991242,0.00005895979,0.00004012411,0.0004767989],"study_design_scores_gemma":[0.00001114075,0.0001163218,0.003414957,0.000002984536,0.000008403501,0.0001897396,0.000009417678,0.0005172719,0.9945797,0.00002341543,0.001123363,0.000003281506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934065,0.001854511,0.00193162,0.0001251264,0.0000396221,0.00002233416,0.0005749507,0.0001348103,0.001910384],"genre_scores_gemma":[0.9936051,0.001098165,0.002054507,0.00006381927,0.00001329261,0.00004200693,0.0005517956,0.00002432471,0.00254707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009099048,"threshold_uncertainty_score":0.00304389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00626827785474302,"score_gpt":0.2081276572917818,"score_spread":0.2018593794370387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}