{"id":"W2014179352","doi":"10.1200/jco.2014.56.3296","title":"SWOG S0221: A Phase III Trial Comparing Chemotherapy Schedules in High-Risk Early-Stage Breast Cancer","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Texas MD Anderson Cancer Center; Loyola University Chicago Stritch School of Medicine; U.S. Public Health Service; Louisiana State University; Genentech; Barbara Ann Karmanos Cancer Institute; Georgetown University; University of Arizona Cancer Center; National Cancer Institute; Cleveland Clinic; Canadian Cancer Society Research Institute; U.S. Department of Health and Human Services; Wayne State University; Loyola University Chicago","keywords":"Medicine; Taxane; Breast cancer; Anthracycline; Internal medicine; Cyclophosphamide; Oncology; Hazard ratio; Randomization; Paclitaxel; Interim analysis; Chemotherapy; Cancer; Stage (stratigraphy); Gynecology; Randomized controlled trial; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002107905,0.00129879,0.00159783,0.0004866273,0.0003057087,0.0006632961,0.0007311751,0.001001016,0.00654095],"category_scores_gemma":[0.001490442,0.0003024072,0.001049699,0.0005615673,0.00084729,0.0004959284,0.0003306696,0.001940822,0.0008237723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008054951,"about_ca_system_score_gemma":0.002278558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009386744,"about_ca_topic_score_gemma":0.003480501,"domain_scores_codex":[0.9993232,0.0004839169,0.00002708886,0.000059592,0.00005113075,0.00005516481],"domain_scores_gemma":[0.9991635,0.0002303912,0.0001856781,0.00004632762,0.00004305462,0.0003310941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8521508,0.0252226,0.002848863,0.001156837,0.000863105,0.0001371723,0.0001059449,0.002946646,0.01286512,0.0003159384,0.003856111,0.09753095],"study_design_scores_gemma":[0.8177493,0.1738315,0.003585192,0.00006158653,0.0002791582,0.0001159188,0.00002312929,0.001044406,0.001052455,0.0001652559,0.002075999,0.00001605533],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905488,0.003207708,0.0005314952,0.0007222511,0.0002374404,0.00194368,0.0007835772,0.00006908077,0.001955903],"genre_scores_gemma":[0.9786839,0.003483812,0.003500601,0.001675735,0.0004625276,0.004218377,0.002834511,0.00004437023,0.005096329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00654095,"threshold_uncertainty_score":0.0218817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05815462024215362,"score_gpt":0.4355407294356332,"score_spread":0.3773861091934795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}