{"id":"W2014179352","doi":"10.1200/jco.2014.56.3296","title":"SWOG S0221: A Phase III Trial Comparing Chemotherapy Schedules in High-Risk Early-Stage Breast Cancer","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Texas MD Anderson Cancer Center; Loyola University Chicago Stritch School of Medicine; U.S. Public Health Service; Louisiana State University; Genentech; Barbara Ann Karmanos Cancer Institute; Georgetown University; University of Arizona Cancer Center; National Cancer Institute; Cleveland Clinic; Canadian Cancer Society Research Institute; U.S. Department of Health and Human Services; Wayne State University; Loyola University Chicago","keywords":"Medicine; Taxane; Breast cancer; Anthracycline; Internal medicine; Cyclophosphamide; Oncology; Hazard ratio; Randomization; Paclitaxel; Interim analysis; Chemotherapy; Cancer; Stage (stratigraphy); Gynecology; Randomized controlled trial; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001925006,0.000204848,0.001266774,0.00007778256,0.00006055005,0.00001402194,0.0002795685,0.0003697992,0.00006481598],"category_scores_gemma":[0.0005120907,0.0001580195,0.0003738281,0.00009349626,0.0002277062,0.00001153687,0.00009413678,0.0005668917,0.000004721888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009264243,"about_ca_system_score_gemma":0.0004902227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008541658,"about_ca_topic_score_gemma":0.001259004,"domain_scores_codex":[0.9970484,0.0005490155,0.001598174,0.0003006092,0.0002037728,0.0002999667],"domain_scores_gemma":[0.9974381,0.0003545069,0.001584355,0.0002347925,0.0001969377,0.0001912667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2171887,0.004277803,0.5608624,0.00001378809,0.001192055,0.00004676315,0.0001178059,0.0002619467,0.0007722483,0.0001759744,0.001158234,0.2139323],"study_design_scores_gemma":[0.3434862,0.008949546,0.6179779,0.00005853481,0.000212833,0.00003884096,0.00007522199,0.0001168744,0.000804539,0.0002328442,0.0277903,0.0002564013],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951221,0.0004373486,0.0004779465,0.002157177,0.001336976,0.0001757806,0.00002368646,0.000005252266,0.0002637016],"genre_scores_gemma":[0.9921681,0.002446947,0.001093926,0.000769521,0.003416664,0.00001887399,0.000005336106,0.00002331211,0.00005733325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2136759,"threshold_uncertainty_score":0.6443847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05815462024215362,"score_gpt":0.4355407294356332,"score_spread":0.3773861091934795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}