{"id":"W2014193488","doi":"10.1186/1471-2091-9-s1-s6","title":"The UPS in diabetes and obesity","year":2008,"lang":"en","type":"review","venue":"BMC Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Genome Canada","keywords":"Insulin receptor substrate; Insulin receptor; Insulin; IRS2; IRS1; Insulin resistance; Internalization; Type 2 diabetes; Biology; Ubiquitin; Endocrinology; Proteasome; Internal medicine; Protein kinase B; Signal transduction; Diabetes mellitus; Cell biology; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001909834,0.0003555629,0.0005033955,0.00002260227,0.0001467785,0.00003962384,0.0003722988,0.0006001466,0.000005378226],"category_scores_gemma":[0.0001947226,0.0002558217,0.0002339037,0.0001012657,0.0002205142,0.000001176861,0.0002876587,0.0002917786,0.00001183643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002410851,"about_ca_system_score_gemma":0.0003145029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000243087,"about_ca_topic_score_gemma":0.000008655108,"domain_scores_codex":[0.9985816,0.00009966142,0.0003367188,0.000521581,0.0001066824,0.0003536906],"domain_scores_gemma":[0.9990688,0.00007350166,0.0001596093,0.0005777963,0.0000255845,0.00009471059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002800137,0.0001760156,0.004183027,0.02443627,0.0002335189,0.00002186962,0.00003095835,2.476799e-7,0.007170063,0.0000396151,0.009263258,0.9544172],"study_design_scores_gemma":[0.0001377782,0.00002513293,0.00003112506,0.001036246,0.00003260878,0.00005682607,0.000008700777,9.533712e-7,0.01884243,0.00001506121,0.9794665,0.0003466488],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01028404,0.9881758,0.000002520692,0.000005752239,0.00006895583,0.0003046601,0.00004871339,0.00001122779,0.001098299],"genre_scores_gemma":[0.0004219629,0.997539,0.0001242406,0.00002410818,0.0003365759,0.0001411458,0.0002460619,0.00003759091,0.001129278],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9702032,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241115499191761,"score_gpt":0.2733649455612309,"score_spread":0.2492533956420548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}