{"id":"W2014199818","doi":"10.1007/s00125-005-0123-1","title":"Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration","year":2006,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Canadian Diabetes Association","keywords":"Internal medicine; Endocrinology; Bicuculline; gamma-Aminobutyric acid; Insulin; Islet; Secretion; Membrane potential; Chemistry; Beta cell; GABAergic; GABAA receptor; Biology; Endogeny; Inhibitory postsynaptic potential; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510156,0.0007169703,0.0006786275,0.0004266636,0.0002184438,0.0007300187,0.0002571896,0.0003159955,0.001864256],"category_scores_gemma":[0.0001966209,0.0003278324,0.0005310271,0.0002949965,0.0004244838,0.0003610468,0.0003652545,0.0009801876,0.0004035281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005795902,"about_ca_system_score_gemma":0.0003525635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006952857,"about_ca_topic_score_gemma":0.0009407296,"domain_scores_codex":[0.9997171,0.00005599545,0.00003341939,0.00005148541,0.00005598435,0.00008610261],"domain_scores_gemma":[0.9997388,0.00004938174,0.00004898815,0.00004039933,0.00002505489,0.00009740552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001307285,0.000035204,0.0003264608,0.00003361176,0.00001273415,0.0001116298,0.00001016177,0.00001934086,0.9965461,0.00005237544,0.00004101338,0.001504158],"study_design_scores_gemma":[0.0001194854,0.0006369961,0.01567048,0.00001259338,0.0000462116,0.0002547469,0.0000679317,0.000292348,0.9816239,0.00008464394,0.00118345,0.000007139588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908274,0.004928245,0.001140368,0.0003799598,0.0002766968,0.00002053681,0.0001972387,0.00007550442,0.00215393],"genre_scores_gemma":[0.9910505,0.002650104,0.00157151,0.0002380494,0.00009841428,0.00003703956,0.0003556236,0.0000473338,0.003951448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864256,"threshold_uncertainty_score":0.006236553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009632552297387985,"score_gpt":0.2131531796163971,"score_spread":0.2035206273190091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}