{"id":"W2014208111","doi":"10.1089/109662003772519868","title":"<i>In Vitro</i> Anti-Cancer Activities in Caco-2 and HCT-116 Cells of Recombinant Cystatin C Prepared by a <i>Pichia</i> Expression System","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Food","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pepstatin; Pichia pastoris; Cystatin; Protease inhibitor (pharmacology); Cathepsin C; Cathepsin B; Molecular biology; In vitro; Recombinant DNA; Chemistry; Protease; Matrix metalloproteinase; Cystatin C; Cell culture; Biology; Biochemistry; Enzyme; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005041972,0.0001269318,0.0003404247,0.00008382976,0.00002071707,0.000006023285,0.0000914684,0.0001110113,0.000006111123],"category_scores_gemma":[0.00004215961,0.00009885604,0.00005820151,0.00006789995,0.00003692014,0.00001552756,0.00002504993,0.0001588237,1.361196e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003089698,"about_ca_system_score_gemma":0.0001228676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002505196,"about_ca_topic_score_gemma":0.000009740384,"domain_scores_codex":[0.9988068,0.0001685021,0.0004713182,0.0001529454,0.0002226341,0.0001777427],"domain_scores_gemma":[0.999366,0.00001990166,0.0003707716,0.0001095442,0.00004993102,0.00008384386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004398477,0.0001227085,0.0001410505,0.0001342212,0.00002144335,0.00001913979,0.0001477979,0.00000478628,0.9956557,0.0000147779,0.003083149,0.0002153831],"study_design_scores_gemma":[0.002233264,0.001291801,0.00001130602,0.0005771981,0.00001853592,0.00009358751,0.0008958235,0.000008107147,0.9923997,0.00004781571,0.002325367,0.00009751174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927955,0.006075161,0.0002172202,0.00006442406,0.0004665311,0.0001462434,0.00002010553,0.000001340028,0.0002135185],"genre_scores_gemma":[0.9985334,0.0008092588,0.0003849305,0.00008785759,0.00008244387,0.000008976701,0.000002616197,0.00001188401,0.00007865043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005737925,"threshold_uncertainty_score":0.4031232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004723811139507855,"score_gpt":0.2238890395530811,"score_spread":0.2191652284135732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}