{"id":"W2014210756","doi":"10.1111/jnc.12176","title":"Calmodulin Kinase <scp>IV</scp>–dependent <scp>CREB</scp> activation is required for neuroprotection via <scp>NMDA</scp> receptor‐<scp>PSD</scp>95 disruption","year":2013,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canadian Stroke Network","keywords":"CREB; Neuroprotection; Excitotoxicity; NMDA receptor; Kinase; Phosphorylation; Protein kinase A; Cell biology; Chemistry; Glutamate receptor; Pharmacology; Biology; Receptor; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007905462,0.0003149708,0.0003328028,0.0001603714,0.0002378173,0.0003298991,0.0002996723,0.0002788973,0.002310567],"category_scores_gemma":[0.0001284824,0.0001541795,0.0002922994,0.0001464785,0.0003447745,0.0001954875,0.0001939293,0.0007819318,0.0005760895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005822595,"about_ca_system_score_gemma":0.0004230985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708449,"about_ca_topic_score_gemma":0.002625593,"domain_scores_codex":[0.9998521,0.00001293312,0.00001198353,0.0000269862,0.00004218686,0.00005376176],"domain_scores_gemma":[0.9999142,0.000006984949,0.00003000783,0.000009001276,0.000008969836,0.00003085027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001116772,0.00001671687,0.00005631162,0.00002609606,0.000003562994,0.00002902995,0.000006760014,0.00001800718,0.9992718,0.00006063427,0.00003993282,0.0003594922],"study_design_scores_gemma":[0.00004456902,0.0001599166,0.005914462,0.000009266326,0.00001244375,0.0001965956,0.00002206097,0.0007610635,0.9908262,0.00006634377,0.001982595,0.000004598307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941474,0.001148123,0.001923324,0.0001814775,0.00004721498,0.00004231565,0.0005690451,0.000100709,0.00184031],"genre_scores_gemma":[0.9943808,0.000595186,0.001497267,0.0000632124,0.00001663744,0.00006979108,0.0007971581,0.00003150432,0.002548471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002310567,"threshold_uncertainty_score":0.00772965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03960024492498712,"score_gpt":0.3116241094082771,"score_spread":0.27202386448329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}