{"id":"W2014256027","doi":"10.1073/pnas.0510645103","title":"Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nerve growth factor; Neurotrophin; Cell biology; Tissue plasminogen activator; Growth factor; Extracellular; Biology; Protease; Neuroscience; Chemistry; Endocrinology; Internal medicine; Biochemistry; Enzyme; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004492883,0.0001676016,0.0001972097,0.0002209956,0.0002879811,0.00004990343,0.0005408149,0.0001493238,0.00001085468],"category_scores_gemma":[0.00100169,0.0001149492,0.00007391775,0.0007849587,0.0003617141,0.00121334,0.0001441342,0.0002287068,0.000001260633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005312005,"about_ca_system_score_gemma":0.00004528043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000621947,"about_ca_topic_score_gemma":3.28286e-7,"domain_scores_codex":[0.9975213,0.0000390467,0.0003547451,0.0004602916,0.001428511,0.0001961104],"domain_scores_gemma":[0.9987746,0.0001502763,0.0006430311,0.00001394137,0.0003393702,0.00007873819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008400314,0.0001335834,0.00143081,0.0001487429,0.00000327819,3.351719e-8,0.0001048429,0.00002072108,0.983823,0.0135547,0.0005970747,0.00009919429],"study_design_scores_gemma":[0.000249678,0.000181095,0.01145612,0.00007949667,0.00001095169,0.00001000307,0.00002470451,0.0006342396,0.9827601,0.004443984,0.00002278001,0.0001269004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956785,0.00008471612,0.000006126841,0.002921951,0.00003896595,0.0006648672,0.0002263418,0.00001792039,0.0003605942],"genre_scores_gemma":[0.9990972,0.00002149306,0.0001664159,0.0001341531,0.00005829356,0.00002167149,7.454194e-7,0.000007313146,0.0004926655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01002531,"threshold_uncertainty_score":0.4687491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03271145483143947,"score_gpt":0.2799391282687228,"score_spread":0.2472276734372833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}