{"id":"W2014271351","doi":"10.1007/s10637-006-9021-8","title":"A phase I study of oral LY293111 given daily in combination with irinotecan in patients with solid tumours","year":2006,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Irinotecan; Medicine; Pharmacology; Pharmacokinetics; Tolerability; Active metabolite; SN-38; Chemotherapy; Oral administration; Internal medicine; Cancer; Adverse effect; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001273975,0.002050225,0.005089582,0.000813722,0.0008162129,0.001650843,0.001312008,0.001875755,0.003978975],"category_scores_gemma":[0.000994657,0.001100914,0.002360504,0.0008507801,0.001874907,0.001472743,0.0005435271,0.006001089,0.001315541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001515355,"about_ca_system_score_gemma":0.002583818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002543003,"about_ca_topic_score_gemma":0.004473221,"domain_scores_codex":[0.9993029,0.0003137617,0.00002942554,0.0001220055,0.00005211488,0.0001798614],"domain_scores_gemma":[0.9991363,0.0001760111,0.0001040452,0.0001062121,0.0000409751,0.0004364072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7527243,0.07927698,0.004449694,0.001122971,0.002079767,0.0006584376,0.0004955235,0.004328164,0.05121598,0.0005429065,0.003982676,0.09912254],"study_design_scores_gemma":[0.4943269,0.49102,0.005068065,0.00002771748,0.000592428,0.000436667,0.00009449127,0.001163388,0.004466124,0.000161064,0.002595735,0.00004750998],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904104,0.002728474,0.0007033474,0.0007890316,0.0002324021,0.001832638,0.0009274605,0.0001540798,0.00222214],"genre_scores_gemma":[0.9867775,0.003565255,0.001580797,0.000649846,0.0002451606,0.001903788,0.001782622,0.00007621037,0.003418849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005089582,"threshold_uncertainty_score":0.01331097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007061497655436181,"score_gpt":0.2394392380634404,"score_spread":0.2323777404080042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}