{"id":"W2014271351","doi":"10.1007/s10637-006-9021-8","title":"A phase I study of oral LY293111 given daily in combination with irinotecan in patients with solid tumours","year":2006,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Irinotecan; Medicine; Pharmacology; Pharmacokinetics; Tolerability; Active metabolite; SN-38; Chemotherapy; Oral administration; Internal medicine; Cancer; Adverse effect; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009522273,0.0001534732,0.0001673303,0.000151551,0.00002805189,0.00001314303,0.0001191217,0.00006998335,0.000005962077],"category_scores_gemma":[0.00002539589,0.0001341189,0.00001501621,0.0003139384,0.000100969,0.00001935062,0.00003293358,0.0001093205,0.000001201555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005362411,"about_ca_system_score_gemma":0.0002710671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007915401,"about_ca_topic_score_gemma":0.0006168862,"domain_scores_codex":[0.9988902,0.00007707227,0.000274483,0.0002859531,0.0003014028,0.0001709545],"domain_scores_gemma":[0.9995093,0.000009765446,0.0001482157,0.000141072,0.0001213157,0.00007033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006442613,0.003912312,0.9502208,0.000009273163,0.00003033098,0.00000273185,0.0004622681,0.002794723,0.04121928,0.00005637399,0.000254918,0.0003927101],"study_design_scores_gemma":[0.03105598,0.005924697,0.685314,0.00008203804,0.00001899198,0.000001977833,0.0003841491,0.0001606429,0.2760681,0.0004527479,0.0001584719,0.0003782377],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992067,0.00001227524,0.00003531743,0.00015412,0.00002185013,0.0004529162,0.00001316348,0.000007666553,0.00009599078],"genre_scores_gemma":[0.9988346,4.810087e-7,0.0006068118,0.00006363877,0.00002872982,0.00003178979,0.0003627065,0.00002048943,0.00005082153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2649068,"threshold_uncertainty_score":0.5469211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007061497655436181,"score_gpt":0.2394392380634404,"score_spread":0.2323777404080042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}