{"id":"W2014283693","doi":"10.1110/ps.37302","title":"Expression, purification, and activities of full‐length and truncated versions of the integral membrane protein Vpu from HIV‐1","year":2002,"lang":"en","type":"article","venue":"Protein Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Cancer Institute; National Center for Research Resources; Medical Research Council; National Institute of General Medical Sciences; Medical Research Council Canada","keywords":"Transmembrane domain; Transmembrane protein; Helix (gastropod); Biophysics; Cytoplasm; Integral membrane protein; Membrane protein; Lipid bilayer; Nuclear magnetic resonance spectroscopy; Protein secondary structure; Membrane; Biology; Crystallography; Chemistry; Biochemistry; Stereochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000208707,0.00007940864,0.0001280836,0.00007327791,0.0002677924,0.00001237316,0.0002567617,0.00005216042,0.0002427518],"category_scores_gemma":[0.0002431487,0.00004685626,0.00002081719,0.0002332278,0.001826821,0.0001497795,0.0001418528,0.0001217724,0.00001637273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001516201,"about_ca_system_score_gemma":0.00005827695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001579594,"about_ca_topic_score_gemma":0.00001115847,"domain_scores_codex":[0.9992431,0.0001156979,0.0001417688,0.0002257601,0.00009323683,0.0001804244],"domain_scores_gemma":[0.9994766,0.00006196105,0.00009511059,0.0002613754,0.00007485222,0.0000300928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004507361,0.00009390229,0.0009472873,0.0000122427,0.00001193242,2.655379e-7,0.0009374691,1.500979e-7,0.9948558,0.0002408205,0.0000618046,0.002793285],"study_design_scores_gemma":[0.0005177928,0.0001194064,0.006189516,0.00008682365,0.000005939391,0.000003837423,0.000422319,0.00001566047,0.9919286,0.0001674616,0.0004948063,0.0000477751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971759,0.001247288,0.00003703076,0.0005182856,0.00002389163,0.0005868256,0.00009083703,0.00001018897,0.0003097378],"genre_scores_gemma":[0.9984336,0.00004523038,0.0005189305,0.000004061893,0.000002819273,0.00006880571,0.000005619379,0.000002859952,0.000918025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005242229,"threshold_uncertainty_score":0.6730999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716185451442331,"score_gpt":0.2316595140694082,"score_spread":0.2144976595549848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}