{"id":"W2014283693","doi":"10.1110/ps.37302","title":"Expression, purification, and activities of full‐length and truncated versions of the integral membrane protein Vpu from HIV‐1","year":2002,"lang":"en","type":"article","venue":"Protein Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Cancer Institute; National Center for Research Resources; Medical Research Council; National Institute of General Medical Sciences; Medical Research Council Canada","keywords":"Transmembrane domain; Transmembrane protein; Helix (gastropod); Biophysics; Cytoplasm; Integral membrane protein; Membrane protein; Lipid bilayer; Nuclear magnetic resonance spectroscopy; Protein secondary structure; Membrane; Biology; Crystallography; Chemistry; Biochemistry; Stereochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881465,0.0003791701,0.0002819045,0.0001825566,0.0002481087,0.000473899,0.0003394993,0.0003049312,0.0002503361],"category_scores_gemma":[0.0004488493,0.0002048596,0.0003186836,0.0003476652,0.0003335474,0.0003686464,0.0002613206,0.0005144464,0.0001352581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008471516,"about_ca_system_score_gemma":0.0002827524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482211,"about_ca_topic_score_gemma":0.0009271884,"domain_scores_codex":[0.9997435,0.00006255016,0.00003544863,0.00004881262,0.00006920603,0.00004051744],"domain_scores_gemma":[0.9998777,0.00002982936,0.00002660877,0.00002472193,0.00001809456,0.00002299196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001364832,0.00002774379,0.0002202833,0.00003247703,0.000007616652,0.00003756309,0.00003680021,0.0003197257,0.998458,0.0001425973,0.00002061533,0.0005600577],"study_design_scores_gemma":[0.00002824584,0.0002945753,0.004169148,0.00001095631,0.00002552344,0.0003761582,0.00005948124,0.00262781,0.9903928,0.0001013021,0.001903589,0.00001051535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972446,0.0009252781,0.001185457,0.00003912661,0.000008294799,0.00001072744,0.0003594962,0.00001093627,0.0002160403],"genre_scores_gemma":[0.9898046,0.0009885964,0.004948881,0.00003235238,0.000009876239,0.00004553575,0.003123991,0.00002581527,0.001020314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482211,"threshold_uncertainty_score":0.006146491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716185451442331,"score_gpt":0.2316595140694082,"score_spread":0.2144976595549848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}