{"id":"W2014348387","doi":"10.1159/000224636","title":"Genome Scan, Fine-Mapping, and Candidate Gene Analysis of Non-Syndromic Cleft Lip with or without Cleft Palate Reveals Phenotype-Specific Differences in Linkage and Association Results","year":2009,"lang":"en","type":"article","venue":"Human Heredity","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; BC Research (Canada); University of British Columbia","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; March of Dimes Foundation; National Institutes of Health; National Human Genome Research Institute; Johns Hopkins University; Hope Foundation","keywords":"Candidate gene; Genetics; Single-nucleotide polymorphism; Genome-wide association study; Phenotype; Genetic linkage; Genome; Genetic association; Linkage (software); Biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071663,0.0003255196,0.0003142998,0.001382135,0.000274057,0.0003311618,0.0003555473,0.0003364458,0.002983276],"category_scores_gemma":[0.00360164,0.0001757272,0.0005277598,0.0008512678,0.0002805183,0.0001133803,0.0004989326,0.0002971315,0.0002161142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992557,"about_ca_system_score_gemma":0.0002709455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003253878,"about_ca_topic_score_gemma":0.004404933,"domain_scores_codex":[0.9990809,0.000396178,0.00006323221,0.0002671711,0.0001251789,0.00006728647],"domain_scores_gemma":[0.9986967,0.0007409642,0.0003204939,0.00008085185,0.00007926761,0.00008174212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007983427,0.0001390997,0.9266871,0.00009735585,0.0005904129,0.001711851,0.0002521631,0.0008318608,0.03874131,0.000308325,0.0004878435,0.02935423],"study_design_scores_gemma":[0.00005863233,0.0001616234,0.9906468,0.00001144748,0.00017543,0.003617161,0.00008400712,0.001151302,0.00343492,0.0002042909,0.0004467541,0.000007638631],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997335,0.0004024149,0.001473754,0.0000464524,0.000002937859,0.00001399629,0.0002572105,0.00002641555,0.0004417628],"genre_scores_gemma":[0.9966308,0.0001622628,0.002452895,0.00003420271,0.000004310775,0.00002185131,0.0004205506,0.00001180209,0.0002613034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003253878,"threshold_uncertainty_score":0.009980023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02629556798395929,"score_gpt":0.2794754490371429,"score_spread":0.2531798810531836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}