{"id":"W2014356708","doi":"10.1038/sj.onc.1203817","title":"Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner","year":2000,"lang":"en","type":"article","venue":"Oncogene","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":222,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McMaster University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Medical Research Council","keywords":"Biology; Angiogenesis; Cancer research; Vascular endothelial growth factor; Vascular endothelial growth factor A; HIF1A; Transcription factor; Molecular biology; Gene; VEGF receptors; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005884579,0.0003575684,0.0004920111,0.000139152,0.0002462864,0.000096599,0.0003934062,0.0001515905,0.0083677],"category_scores_gemma":[0.00009190226,0.000191164,0.0002596986,0.0003903519,0.0002391669,0.0001107556,0.0001613675,0.0004496697,0.0001256424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894252,"about_ca_system_score_gemma":0.000285266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001737014,"about_ca_topic_score_gemma":0.0008812679,"domain_scores_codex":[0.9971139,0.0002598538,0.0004159342,0.0006114431,0.0009084725,0.0006904078],"domain_scores_gemma":[0.9987059,0.0001560165,0.00006915797,0.0006619691,0.0001444013,0.0002625603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002568722,0.0008506145,0.02344002,0.0003138981,0.0006367949,0.0004576233,0.002317586,0.00001376225,0.2059375,0.00006518447,0.000529747,0.7628686],"study_design_scores_gemma":[0.006867401,0.0009311371,0.3197045,0.0000816407,0.0002535286,0.0004036743,0.0004553385,0.0001372078,0.6094379,0.0005606613,0.06056019,0.000606903],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838006,0.006306765,0.00001522681,0.003597103,0.00007517721,0.001628286,0.00007252477,0.00004993592,0.004454356],"genre_scores_gemma":[0.993971,0.001540236,0.00009368474,0.001252524,0.0008825682,0.0004075276,0.00002437693,0.00007189641,0.00175612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7622617,"threshold_uncertainty_score":0.9925388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02009691796122808,"score_gpt":0.2774543577930305,"score_spread":0.2573574398318024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}