{"id":"W2014396315","doi":"10.1128/jvi.78.10.5476-5485.2004","title":"Impact of Mutations in the Coreceptor Binding Site on Human Immunodeficiency Virus Type 1 Fusion, Infection, and Entry Inhibitor Sensitivity","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Manitoba; University of Pennsylvania; U.S. Public Health Service; Elizabeth Glaser Pediatric AIDS Foundation","keywords":"Enfuvirtide; Biology; Infectivity; Virology; Gp41; Lipid bilayer fusion; Viral entry; Mutation; Entry inhibitor; Virus; Fusion protein; Binding site; Viral envelope; Viral replication; Recombinant DNA; Immunology; Biochemistry; Antibody; Gene; Epitope","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004858589,0.0000863262,0.0002039016,0.0002576229,0.0001459351,0.00000662782,0.00005022943,0.0001120251,0.0001100502],"category_scores_gemma":[0.0001432015,0.00005185682,0.00007945376,0.0001672353,0.0002056177,0.00005964626,0.00002392219,0.000364896,0.00008778857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009019029,"about_ca_system_score_gemma":0.0001050399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005174397,"about_ca_topic_score_gemma":0.0002049557,"domain_scores_codex":[0.9990502,0.000362625,0.0002758421,0.00008400104,0.00004514153,0.0001822183],"domain_scores_gemma":[0.9993881,0.0002096031,0.0001994419,0.00009065316,0.00009449705,0.000017685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003793445,0.0006395059,0.1032732,0.000003046736,0.0001007299,0.00005051307,0.0009935917,0.0002049876,0.8935177,0.00006180672,0.0001966354,0.0005789464],"study_design_scores_gemma":[0.002742334,0.005583085,0.9669638,0.00003099835,0.00003432122,0.0008264322,0.00008551226,6.721701e-7,0.02323075,0.0001560731,0.0002875303,0.00005846111],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988835,0.0005471695,0.00001625489,0.000171923,0.0001612305,0.0000973096,0.00003281379,0.000002888557,0.00008688767],"genre_scores_gemma":[0.9996281,0.0002610436,0.00000967185,0.00002851099,0.00002298233,0.000001323029,0.00002657689,0.000004181148,0.00001763127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.870287,"threshold_uncertainty_score":0.211466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02035958767857332,"score_gpt":0.3226942269237673,"score_spread":0.3023346392451939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}