{"id":"W2014396315","doi":"10.1128/jvi.78.10.5476-5485.2004","title":"Impact of Mutations in the Coreceptor Binding Site on Human Immunodeficiency Virus Type 1 Fusion, Infection, and Entry Inhibitor Sensitivity","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Manitoba; University of Pennsylvania; U.S. Public Health Service; Elizabeth Glaser Pediatric AIDS Foundation","keywords":"Enfuvirtide; Biology; Infectivity; Virology; Gp41; Lipid bilayer fusion; Viral entry; Mutation; Entry inhibitor; Virus; Fusion protein; Binding site; Viral envelope; Viral replication; Recombinant DNA; Immunology; Biochemistry; Antibody; Gene; Epitope","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003424253,0.0004992699,0.0003734918,0.0002899161,0.0001766811,0.0003406331,0.0002905661,0.000437269,0.001289192],"category_scores_gemma":[0.0005717585,0.0001931903,0.0003558512,0.0001975279,0.0002553249,0.0002865376,0.0002201701,0.0004825674,0.0001727174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003934526,"about_ca_system_score_gemma":0.000290886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128221,"about_ca_topic_score_gemma":0.001327232,"domain_scores_codex":[0.99961,0.00009604209,0.00006000253,0.00006116561,0.0001022696,0.00007056924],"domain_scores_gemma":[0.9996618,0.0001469449,0.00008146148,0.00002133381,0.00002722034,0.00006120023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003984197,0.0001528839,0.0008504192,0.0000333507,0.00003111539,0.0001670532,0.0000269614,0.0005889199,0.9956985,0.00008616672,0.00003020263,0.001936018],"study_design_scores_gemma":[0.00005508101,0.001961636,0.01057896,0.0000123771,0.00007853686,0.0007390897,0.00004874075,0.002764596,0.9828829,0.00005940271,0.0007931753,0.00002548348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986125,0.0004499435,0.0002597785,0.00001912195,0.000009181833,0.00001979906,0.00009830852,0.00001664598,0.0005147036],"genre_scores_gemma":[0.9990392,0.0002055117,0.0003555351,0.00002612088,0.000002765259,0.00001022515,0.0001327297,0.00001195556,0.0002160131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289192,"threshold_uncertainty_score":0.004312754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02035958767857332,"score_gpt":0.3226942269237673,"score_spread":0.3023346392451939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}