{"id":"W2014415435","doi":"10.1016/j.bmcl.2011.12.104","title":"Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ontario Institute of Technology","funders":"","keywords":"Gene silencing; Small interfering RNA; Chemistry; RNA interference; Luciferase; Cell biology; Molecular biology; RNA; Gene; Biochemistry; Transfection; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143487,0.0002621953,0.0001674842,0.0001286041,0.0001336236,0.0002688894,0.0002192915,0.0002755005,0.0007710977],"category_scores_gemma":[0.0001302727,0.0001189691,0.0001882596,0.0001280296,0.0001565784,0.0001365395,0.0001471061,0.0003122852,0.000326669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003044992,"about_ca_system_score_gemma":0.000212636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008133464,"about_ca_topic_score_gemma":0.001879533,"domain_scores_codex":[0.9999071,0.00001530955,0.00001130302,0.00001834044,0.00002633081,0.00002150038],"domain_scores_gemma":[0.9999294,0.00002097469,0.00001730203,0.0000112989,0.00001153797,0.000009484648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001401732,0.000003346187,0.00001928562,0.000008276839,9.090594e-7,0.00001533204,0.000006066158,0.00002384625,0.9994851,0.0000698143,0.00001331346,0.0003405254],"study_design_scores_gemma":[0.000003089851,0.00002822892,0.0001687584,4.677799e-7,0.000002653466,0.00001786839,0.000002350021,0.0001823471,0.9991153,0.000006055465,0.0004719506,9.876896e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837431,0.001548795,0.01032732,0.00009459408,0.00003344036,0.00005006368,0.0003668337,0.0001515535,0.003684165],"genre_scores_gemma":[0.9929039,0.0006199763,0.003105227,0.0000229936,0.000003835554,0.00002951072,0.0004159565,0.00002108875,0.002877509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008133464,"threshold_uncertainty_score":0.002579629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984897973847071,"score_gpt":0.2099557134161644,"score_spread":0.1901067336776937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}