{"id":"W2014443443","doi":"10.1371/journal.pone.0050716","title":"Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Umeclidinium and Vilanterol Alone and in Combination: A Randomized Crossover Trial","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"","keywords":"Medicine; Cmax; Pharmacology; Pharmacokinetics; Pharmacodynamics; Tolerability; B2 receptor; Crossover study; Adverse effect; Internal medicine; Placebo; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0025072,0.001710448,0.004233648,0.0003968448,0.0005617499,0.001116606,0.001194068,0.001951423,0.007053976],"category_scores_gemma":[0.001547797,0.0008026375,0.001777846,0.0005583822,0.001445146,0.001312353,0.0004713123,0.002819127,0.001445763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007776605,"about_ca_system_score_gemma":0.001238607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004531011,"about_ca_topic_score_gemma":0.0006381457,"domain_scores_codex":[0.9985455,0.0006591537,0.0001180397,0.0003398178,0.0001323174,0.0002051156],"domain_scores_gemma":[0.9986132,0.0002396768,0.0003673988,0.0001496597,0.0001143579,0.0005156256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9798386,0.009995644,0.0003759853,0.0002110573,0.0004606291,0.00002298213,0.00002598151,0.00008098795,0.003117565,0.00002845945,0.0001999557,0.00564216],"study_design_scores_gemma":[0.725127,0.2701843,0.002000825,0.00001958717,0.0005678381,0.00004105321,0.00002226563,0.000330221,0.0009466276,0.00007178746,0.0006683294,0.0000201537],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866157,0.003569924,0.001007563,0.0003188316,0.0004655695,0.005920077,0.0007651828,0.000117419,0.001219822],"genre_scores_gemma":[0.9840186,0.002057628,0.002066287,0.0006982185,0.0006805895,0.006977616,0.0007813314,0.00003412124,0.00268561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007053976,"threshold_uncertainty_score":0.0235979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03573985247745749,"score_gpt":0.3143673360323636,"score_spread":0.2786274835549061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}