{"id":"W2014447661","doi":"10.1016/j.clinbiochem.2014.06.011","title":"Reproducibility and efficiency of serum-derived exosome extraction methods","year":2014,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Microvesicles; Exosome; CD63; Ultracentrifuge; Bradford protein assay; Chemistry; Reproducibility; Albumin; Nanoparticle tracking analysis; Blot; Chromatography; Molecular biology; Biology; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.003650597,0.0001586727,0.0002606255,0.00001326403,0.00004768885,0.00001111339,0.0002304049,0.0003241799,0.00003190426],"category_scores_gemma":[0.008742607,0.0001565712,0.0001728392,0.00007312915,0.0005116551,0.000003538722,0.0002149739,0.000178734,0.000003706181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007069699,"about_ca_system_score_gemma":0.00006423616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001687768,"about_ca_topic_score_gemma":3.294846e-7,"domain_scores_codex":[0.997438,0.0003189558,0.0006296791,0.001310182,0.0001131283,0.0001901119],"domain_scores_gemma":[0.9973447,0.0001774179,0.0002467551,0.001930078,0.0001125991,0.0001884359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007050911,0.0002292579,0.01412876,0.00009310322,0.00002396243,7.299526e-7,0.000004925081,0.000002230338,0.9456316,0.00001086279,0.0001365236,0.03966749],"study_design_scores_gemma":[0.0004496343,0.0001685561,0.01958935,0.00001635702,0.00003579888,0.000009542999,0.00002175219,0.0001782606,0.9776121,0.0002911313,0.001455352,0.0001722146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889834,0.00133314,0.008359463,0.0001122322,0.0001790553,0.0001111395,0.00001521302,0.00002010742,0.0008862829],"genre_scores_gemma":[0.9825948,0.0001265979,0.01646357,0.0001146953,0.0003523319,0.00000632953,0.00003052211,0.00001785855,0.0002933196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03949527,"threshold_uncertainty_score":0.9996071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02777120650797353,"score_gpt":0.4074268795771211,"score_spread":0.3796556730691475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}