{"id":"W2014448626","doi":"10.1016/j.cell.2012.01.033","title":"Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Biology; Telomerase; Telomerase RNA component; Telomerase reverse transcriptase; DNA; RNA; Telomere; Genetics; Cell biology; Computational biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003023076,0.0003579115,0.0005804768,0.0002590808,0.0001357944,0.00002135486,0.0001540007,0.0001602051,0.0001866586],"category_scores_gemma":[0.0000662062,0.0003195477,0.000123875,0.0002919523,0.0002120979,0.0002750418,0.0001234447,0.0002673147,0.00007012802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009948482,"about_ca_system_score_gemma":0.000112458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003959275,"about_ca_topic_score_gemma":0.000001715407,"domain_scores_codex":[0.9978411,0.00006167946,0.0005278193,0.0004341876,0.0004259545,0.00070923],"domain_scores_gemma":[0.9984041,0.0001286981,0.0002313244,0.0004833032,0.00008652395,0.0006660099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002418806,0.0006971951,0.004936607,0.0004069139,0.00007666733,0.0000369168,0.004392798,0.00001832831,0.9692932,0.00005848427,0.006896365,0.01294459],"study_design_scores_gemma":[0.003017809,0.0003533991,0.001468011,0.0002105281,0.0002447072,0.00006161311,0.001613431,0.001380327,0.9817259,0.00003976563,0.009341297,0.0005432505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906535,0.00292764,0.0002603918,0.000310448,0.0002694453,0.0008337678,0.00006212639,0.00007242866,0.00461028],"genre_scores_gemma":[0.9912379,0.001020462,0.002534625,0.0007340165,0.0001612811,0.0000505833,0.00008845016,0.00006153743,0.0041111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01243261,"threshold_uncertainty_score":0.9999257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0446842236221844,"score_gpt":0.2891682182306588,"score_spread":0.2444839946084744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}