{"id":"W2014454732","doi":"10.1002/cbic.201402024","title":"Key Residues in Octyl‐Tridecaptin A<sub>1</sub> Analogues Linked to Stable Secondary Structures in the Membrane","year":2014,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Peptide; Lipopeptide; Chemistry; Circular dichroism; Membrane; Protein secondary structure; Bacteria; Antimicrobial; Amino acid; Alanine; Stereochemistry; Combinatorial chemistry; Antimicrobial peptides; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005445103,0.0002544868,0.0004021005,0.0001869536,0.0001209861,0.00004651862,0.0004289318,0.0002879885,0.0001284546],"category_scores_gemma":[0.0001765699,0.0001975144,0.0000872029,0.0002922232,0.0001911505,0.0001143722,0.0001278403,0.0005489898,0.0001503944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004217451,"about_ca_system_score_gemma":0.00005875298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198661,"about_ca_topic_score_gemma":0.001020329,"domain_scores_codex":[0.9984721,0.0001994107,0.0003561616,0.0004029254,0.00004858643,0.0005208467],"domain_scores_gemma":[0.9991986,0.0002531268,0.00009237049,0.0003923105,0.00003684099,0.00002674503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000120497,0.00006358609,0.0006003436,0.00004244329,0.00002594982,0.000005740496,0.001821229,0.00001898098,0.9840973,0.000699554,0.01011529,0.00238906],"study_design_scores_gemma":[0.0008249719,0.00007785848,0.02227637,0.00006195647,0.00001093298,0.0000201052,0.0011724,0.000001947727,0.9675223,0.0007002278,0.007080406,0.0002504739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944375,0.0006895747,0.00001804089,0.0007608208,0.0001923748,0.0002628894,0.00003581665,0.00004635283,0.003556646],"genre_scores_gemma":[0.9976007,0.0000784045,0.0001043131,0.001484311,0.00008963645,0.00002291888,0.0001684606,0.00002267823,0.0004285944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02167602,"threshold_uncertainty_score":0.8054403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009669669057685739,"score_gpt":0.2129066039498815,"score_spread":0.2032369348921957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}