{"id":"W2014463389","doi":"10.1126/science.1204988","title":"Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Bacterial adhesin; Pathogen; Host (biology); Biology; Receptor; Apicomplexa; Cell biology; Peptide; Computational biology; Microbiology; Biochemistry; Plasmodium falciparum; Ecology; Gene; Immunology; Virulence; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.000116454,0.0001242658,0.0001650884,0.00006015194,0.000451418,0.00001832672,0.0007734413,0.00006202015,0.000304293],"category_scores_gemma":[0.00009155586,0.00006374282,0.00002345329,0.0003237318,0.003156605,0.0001524995,0.0001921803,0.0002408597,0.0001166095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002401521,"about_ca_system_score_gemma":0.0001328466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006521141,"about_ca_topic_score_gemma":0.0004607771,"domain_scores_codex":[0.9990003,0.00009907866,0.0001346757,0.0003280008,0.0001173118,0.0003206753],"domain_scores_gemma":[0.9992007,0.0001851184,0.0001021942,0.0003879149,0.00009544294,0.00002864419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005755635,0.0000380141,0.03015377,0.00000381602,0.00001764704,0.000001565074,0.004387827,3.185789e-7,0.9629783,0.0001349174,0.002133613,0.00009264105],"study_design_scores_gemma":[0.0003468715,0.0002056881,0.1791255,0.00001883581,0.000007634432,0.000004996512,0.001058849,7.792478e-7,0.8133667,0.0002180771,0.005561322,0.00008473454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995596,0.001703196,0.00002612261,0.00005990579,0.00008891967,0.0001863352,0.0001251469,0.00002068499,0.002193717],"genre_scores_gemma":[0.9990827,0.00003878796,0.0002792568,0.00008216779,0.000007132986,0.000004670651,0.00001857384,0.000005454725,0.0004812657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1496117,"threshold_uncertainty_score":0.9995562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02136211053970145,"score_gpt":0.2429932347548232,"score_spread":0.2216311242151218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}