{"id":"W2014483534","doi":"10.1371/journal.pone.0022896","title":"Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Proto-oncogene tyrosine-protein kinase Src; Phosphorylation; Signal transduction; Biology; Kinase; Cell biology; FYN; Cancer research; Chemistry; Molecular biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350069,0.0001166238,0.0001259003,0.00005135991,0.00005376106,0.00001269585,0.00005039378,0.0001629354,0.00001908106],"category_scores_gemma":[0.00008961063,0.0001142609,0.00001591587,0.00004823594,0.00002073534,0.00001189242,0.00007759184,0.00009660691,0.000002015038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007691247,"about_ca_system_score_gemma":0.00002111356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005407167,"about_ca_topic_score_gemma":0.000006908659,"domain_scores_codex":[0.9992487,0.00006336509,0.0001524169,0.0002783127,0.00009610727,0.0001611284],"domain_scores_gemma":[0.9996505,0.000008104375,0.00006354647,0.0001570182,0.00004561779,0.00007516225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242463,0.0002447325,0.0006478919,0.00003337744,0.0000197604,0.000005443946,0.0001846713,1.123688e-7,0.9983988,0.00001872606,0.00001168079,0.0003104905],"study_design_scores_gemma":[0.0006149675,0.0003028686,0.0005126595,0.0002104696,0.00001691455,0.000001537264,0.00008117551,0.00006019448,0.9976854,0.0003528922,0.00001076139,0.0001501738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990155,0.0001877362,0.0001065058,0.00002865516,0.00001649427,0.0002349861,0.00000523119,0.0000147324,0.0003902118],"genre_scores_gemma":[0.9980598,0.00008713263,0.001488232,0.0001333698,0.0000968229,0.00003379679,0.0000443051,0.00001722933,0.00003928758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381726,"threshold_uncertainty_score":0.4659425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07875016960528923,"score_gpt":0.2294338391547727,"score_spread":0.1506836695494835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}