{"id":"W2014486173","doi":"10.1016/j.ejphar.2006.08.077","title":"The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: Off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"","keywords":"Icatibant; Bradykinin; Bradykinin receptor; Chemistry; Pharmacology; Receptor; Antagonist; Receptor antagonist; Endocrinology; B2 receptor; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922004,0.0003875772,0.0003690817,0.0001625508,0.0002337343,0.0003090818,0.0002497454,0.0003602205,0.001615536],"category_scores_gemma":[0.000185298,0.0002084563,0.0001394877,0.0001072203,0.00035479,0.0003329723,0.0001287242,0.001382233,0.0004337206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003281504,"about_ca_system_score_gemma":0.0004298693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004708527,"about_ca_topic_score_gemma":0.001660435,"domain_scores_codex":[0.9998801,0.00002219836,0.000008755587,0.00001054677,0.00003068391,0.00004788937],"domain_scores_gemma":[0.9999374,0.00001849197,0.00001095194,0.000005319322,0.000004587309,0.00002333194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003763673,0.00005702089,0.00007227044,0.00003815136,0.000005317849,0.0001221398,0.00001531613,0.00004156781,0.9970119,0.000249292,0.0001076198,0.001902946],"study_design_scores_gemma":[0.0001120068,0.000627933,0.002406227,0.000004307166,0.00001579622,0.0005782499,0.00001766239,0.0004783612,0.9935378,0.000092245,0.002124306,0.000005072348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880556,0.003828634,0.002415225,0.0003879825,0.00008673595,0.00003412714,0.0001451413,0.00008955105,0.00495701],"genre_scores_gemma":[0.9922211,0.002271591,0.003031889,0.0001481727,0.00004349678,0.00004065012,0.0002078603,0.00001565051,0.002019503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615536,"threshold_uncertainty_score":0.005404472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046974381596585,"score_gpt":0.2503053475621767,"score_spread":0.2398356037462109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}