{"id":"W2014537270","doi":"10.1161/01.cir.0000160366.50210.e9","title":"Pivotal Role of gp91 <sup> <i>phox</i> </sup> -Containing NADH Oxidase in Lipopolysaccharide-Induced Tumor Necrosis Factor-α Expression and Myocardial Depression","year":2005,"lang":"en","type":"article","venue":"Circulation","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Apocynin; Superoxide; NADPH oxidase; Tumor necrosis factor alpha; Oxidase test; Lipopolysaccharide; p38 mitogen-activated protein kinases; Medicine; Endocrinology; Molecular biology; Phosphorylation; Internal medicine; Biochemistry; Chemistry; Biology; Oxidative stress; MAPK/ERK pathway; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233369,0.0001665414,0.0002111875,0.00006448986,0.00009782228,0.00002006604,0.00007129031,0.0001311267,0.000008090755],"category_scores_gemma":[0.00009099591,0.0001634513,0.00007859311,0.00006827459,0.0000287995,0.00001971578,0.0001257354,0.00009365556,0.000002058882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002950078,"about_ca_system_score_gemma":0.00002780839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662433,"about_ca_topic_score_gemma":0.00006059064,"domain_scores_codex":[0.9989485,0.00006452085,0.0002612644,0.0003558559,0.0001436509,0.0002262688],"domain_scores_gemma":[0.9995272,0.00002234399,0.0001149099,0.0002143569,0.00004864043,0.00007260697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009659927,0.00003836325,0.0830147,0.00001551282,0.00001403147,0.000001187763,0.000387103,0.0008339398,0.9079744,0.000006081242,0.00008749546,0.007530536],"study_design_scores_gemma":[0.001137654,0.0001003987,0.1728374,0.0000767682,0.00001554665,0.000008214342,0.0002712068,0.005132834,0.819869,0.00001787402,0.0003287375,0.0002043355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985109,0.0009427257,0.0001216746,0.00002714153,0.00004905954,0.0002246897,0.0000099055,0.00001271996,0.0001011601],"genre_scores_gemma":[0.9994479,0.00003932718,0.0001077254,0.00006961276,0.0002476147,0.00002500595,0.00003815408,0.00001998168,0.000004617454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08982271,"threshold_uncertainty_score":0.6665353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007811208050592849,"score_gpt":0.2301316234823343,"score_spread":0.2223204154317415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}