{"id":"W2014598762","doi":"10.1186/1744-8069-7-68","title":"On the Possible Role of ERK, p38 and CaMKII in the Regulation of CGRP Expression in Morphine-Tolerant Rats","year":2011,"lang":"en","type":"article","venue":"Molecular Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Calcitonin gene-related peptide; MAPK/ERK pathway; Dorsal root ganglion; Internal medicine; Morphine; Chemistry; Endocrinology; p38 mitogen-activated protein kinases; Protein kinase A; Signal transduction; Phosphorylation; Cell biology; Pharmacology; Neuropeptide; Medicine; Spinal cord; Neuroscience; Receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009271295,0.0003555637,0.0002447309,0.000229466,0.0001883443,0.0001388453,0.000218848,0.0002269176,0.001674909],"category_scores_gemma":[0.00008219664,0.000110942,0.0003094035,0.0001090211,0.0002748713,0.0002611582,0.0001558814,0.0005229219,0.0001718869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740795,"about_ca_system_score_gemma":0.0001813211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002983652,"about_ca_topic_score_gemma":0.0004266237,"domain_scores_codex":[0.9999382,0.000005381105,0.000004270401,0.00001215665,0.00001651722,0.00002331739],"domain_scores_gemma":[0.9999439,0.000003175194,0.00001997668,0.000004116439,0.000008193084,0.00002054834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001128854,0.000112955,0.001235904,0.0002207485,0.00001526178,0.0003214476,0.00004379764,0.00006480258,0.9897664,0.0003117369,0.00008297496,0.006695242],"study_design_scores_gemma":[0.0001588488,0.003647013,0.1352976,0.00009784974,0.0001588176,0.001702499,0.0003125545,0.001945621,0.8496584,0.001197536,0.005789662,0.00003367924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917042,0.004702806,0.001872635,0.0002193376,0.00005633782,0.00002912197,0.0001440237,0.00003160181,0.001239904],"genre_scores_gemma":[0.9922464,0.003291127,0.001736957,0.00009108098,0.00003441728,0.00006875068,0.0001569579,0.00000670573,0.002367599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674909,"threshold_uncertainty_score":0.005603194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470045220070045,"score_gpt":0.2249384644619551,"score_spread":0.2102380122612547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}