{"id":"W2014649886","doi":"10.1097/01.lab.0000077008.24259.0d","title":"Intrathecal B-Cell Clonal Expansion, an Early Sign of Humoral Immunity, in the Cerebrospinal Fluid of Patients with Clinically Isolated Syndrome Suggestive of Multiple Sclerosis","year":2003,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; Institut National de la Recherche Scientifique; McGill University; University of Toronto; Montreal Neurological Institute and Hospital; Université de Montréal; Hôpital Notre-Dame","funders":"National Institutes of Health; Multiple Sclerosis Society; National Multiple Sclerosis Society","keywords":"Cerebrospinal fluid; Multiple sclerosis; Humoral immunity; Immunology; Biology; Antibody; B cell; Germinal center; Somatic cell; Immune system; Antigen; Immunity; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002354378,0.0006965847,0.0005592036,0.001237879,0.000738449,0.0005078156,0.0003238987,0.001003839,0.0006458755],"category_scores_gemma":[0.0033799,0.0003056178,0.0001842766,0.000533528,0.0006386367,0.0004904488,0.000241758,0.0008187715,0.0001720589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280869,"about_ca_system_score_gemma":0.0004058946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002048491,"about_ca_topic_score_gemma":0.00196466,"domain_scores_codex":[0.9997379,0.00005589834,0.00004668067,0.00004535091,0.00006738422,0.00004673934],"domain_scores_gemma":[0.9989327,0.0003997881,0.0002784018,0.00005013721,0.00011161,0.0002273702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003468178,0.0003853826,0.8743333,0.0002788617,0.0001659555,0.07012247,0.001505414,0.000226268,0.03291645,0.00009703696,0.0008829563,0.01561779],"study_design_scores_gemma":[0.0001538187,0.001176832,0.8763928,0.0000615561,0.0001852358,0.114781,0.0008686251,0.0005751819,0.004837362,0.000182849,0.000751364,0.00003351605],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983709,0.0006688922,0.00009949794,0.0001302734,0.00001820285,0.00000883845,0.00005268847,0.00001521315,0.0006354669],"genre_scores_gemma":[0.9994466,0.0001833067,0.00008015742,0.0001145931,0.00004576929,0.000005624206,0.00005318362,0.000003172168,0.00006769684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002048491,"threshold_uncertainty_score":0.004073143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01769088742593131,"score_gpt":0.2135291338577854,"score_spread":0.1958382464318541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}