{"id":"W2014697956","doi":"10.1021/bi011746s","title":"Cooperativity and Oligomeric Status of Cardiac Muscarinic Cholinergic Receptors","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Muscarinic acetylcholine receptor; Chemistry; Digitonin; Receptor; Radioligand; Cooperativity; Cholinergic; Biophysics; Muscarinic acetylcholine receptor M2; Stereochemistry; Internal medicine; Endocrinology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009066871,0.0001616765,0.0002023979,0.00001955843,0.00005179197,0.00001487514,0.00009731714,0.0001736817,0.0002657434],"category_scores_gemma":[0.00007235864,0.0001568632,0.00009075662,0.00009462051,0.00009469174,0.000002972924,0.00008705143,0.00008108102,0.000004483825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001220903,"about_ca_system_score_gemma":0.0000280212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002330567,"about_ca_topic_score_gemma":7.036815e-7,"domain_scores_codex":[0.9990485,0.00003069793,0.000197659,0.0003335429,0.0001125981,0.0002770592],"domain_scores_gemma":[0.9994045,0.000009225417,0.00008386513,0.0002878384,0.00006583639,0.0001487459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001129639,0.000038752,0.001354353,0.00003774586,0.00003897327,3.572077e-7,0.00003440873,0.000008979934,0.99142,0.00001117552,0.001372865,0.005671042],"study_design_scores_gemma":[0.0002065998,0.00009272932,0.0002201119,0.00001230164,0.00001411837,0.000003828172,0.00007239596,0.0001057908,0.9830114,0.000004955552,0.01607126,0.0001844715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905628,0.006864181,0.00005139923,0.00001571553,0.0001852781,0.00007371692,0.00003120443,0.00001134868,0.002204356],"genre_scores_gemma":[0.9933825,0.00400879,0.0005802862,0.00003358788,0.0002192453,0.00001079924,0.00006472079,0.00001967633,0.001680366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01469839,"threshold_uncertainty_score":0.6396696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122763737932638,"score_gpt":0.222929584957309,"score_spread":0.2117019475779826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}