{"id":"W2014697956","doi":"10.1021/bi011746s","title":"Cooperativity and Oligomeric Status of Cardiac Muscarinic Cholinergic Receptors","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Muscarinic acetylcholine receptor; Chemistry; Digitonin; Receptor; Radioligand; Cooperativity; Cholinergic; Biophysics; Muscarinic acetylcholine receptor M2; Stereochemistry; Internal medicine; Endocrinology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100818,0.000244853,0.0004115439,0.0006023183,0.0003180847,0.0009666613,0.0005587842,0.0004416868,0.001087612],"category_scores_gemma":[0.00148105,0.0003811598,0.0004324169,0.0001975682,0.0005846808,0.000829917,0.0004769089,0.0004194826,0.0003949156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004683899,"about_ca_system_score_gemma":0.000207417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005372989,"about_ca_topic_score_gemma":0.0008154399,"domain_scores_codex":[0.9990264,0.0001486021,0.0001064084,0.0003328373,0.0002186528,0.0001672014],"domain_scores_gemma":[0.9983146,0.0006354317,0.0003247099,0.000327217,0.0002296297,0.0001684218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002224937,0.00004322528,0.005814173,0.00005029291,0.0000295544,0.0001092901,0.0001376517,0.0002076908,0.9910279,0.0004784007,0.00003237618,0.001846991],"study_design_scores_gemma":[0.0001167469,0.001025144,0.2879599,0.00004911133,0.000316657,0.002800311,0.0007594127,0.01964334,0.6802936,0.002198224,0.004746851,0.00009056244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996842,0.0006137175,0.001406598,0.00003869371,0.000005468849,0.00001498107,0.00004679907,0.00002759461,0.001004157],"genre_scores_gemma":[0.9984095,0.0002737524,0.0006042016,0.00002095659,0.000009672794,0.0000179931,0.0002029319,0.000008110668,0.0004529809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087612,"threshold_uncertainty_score":0.005331814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122763737932638,"score_gpt":0.222929584957309,"score_spread":0.2117019475779826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}