{"id":"W2014705718","doi":"10.1074/jbc.m110.140004","title":"Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Phosphodiesterase; Cell biology; VE-cadherin; Intracellular; Cadherin; Vascular permeability; Signal transduction; Biology; Endothelial stem cell; Protein kinase A; Biochemistry; Cell; Chemistry; Phosphorylation; Enzyme; Endocrinology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237692,0.0002163973,0.0002623061,0.0002809523,0.0002564464,0.0002890131,0.0001950704,0.0002653578,0.00130139],"category_scores_gemma":[0.0001403884,0.0002084706,0.0002979218,0.0001619264,0.0003077518,0.0001857574,0.0003977415,0.000459519,0.0005507636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006298108,"about_ca_system_score_gemma":0.0002384005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009360651,"about_ca_topic_score_gemma":0.001099788,"domain_scores_codex":[0.9998351,0.00002850282,0.00001672338,0.00004445224,0.00004248564,0.00003277462],"domain_scores_gemma":[0.9999418,0.00001136881,0.00001538838,0.00001086542,0.000007727852,0.00001277138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003721959,0.000007300036,0.0001769283,0.00001558868,0.000002939737,0.00002497211,0.000005456686,0.00008803756,0.9987941,0.00009896433,0.00002027519,0.0007280865],"study_design_scores_gemma":[0.000009320259,0.00007538924,0.003214867,0.000002904551,0.000009745375,0.0001618812,0.00002127863,0.001448741,0.9921116,0.00006356098,0.00287664,0.00000417969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897461,0.001322819,0.006736321,0.0001694059,0.00003386383,0.00002199686,0.0002809062,0.00006168395,0.001626796],"genre_scores_gemma":[0.9874337,0.0007160132,0.007310156,0.00008860587,0.000008285872,0.00003038597,0.0004591099,0.00001621661,0.003937536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130139,"threshold_uncertainty_score":0.00456965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176219311874842,"score_gpt":0.2480888890944963,"score_spread":0.2304669579070121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}