{"id":"W2014707698","doi":"10.1007/s00726-013-1589-7","title":"Aminooxy analog of histamine is an efficient inhibitor of mammalian l-histidine decarboxylase: combined in silico and experimental evidence","year":2013,"lang":"en","type":"article","venue":"Amino Acids","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Musculoskeletal Health and Arthritis; Russian Foundation for Basic Research; Ministry of Education and Science of the Russian Federation; Universidad de Málaga; Junta de Andalucía; Ministerio de Economía y Competitividad; Itä-Suomen Yliopisto","keywords":"Histidine decarboxylase; Histidine; In silico; Imidazole; Chemistry; Histamine; Active site; Oxime; Stereochemistry; Decarboxylation; Enzyme; Pyridoxal; Biochemistry; Biology; Pharmacology; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000577832,0.0004248747,0.0005038259,0.0001390488,0.0001505802,0.000689215,0.0005653334,0.0005100693,0.001352471],"category_scores_gemma":[0.0006596256,0.0001961658,0.0003505163,0.0001275215,0.0002929751,0.0003665959,0.0001791981,0.0004893034,0.0004365154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005484489,"about_ca_system_score_gemma":0.000306722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062276,"about_ca_topic_score_gemma":0.001002396,"domain_scores_codex":[0.9997292,0.00008072753,0.00001478746,0.00006676311,0.00007144795,0.00003693851],"domain_scores_gemma":[0.9995838,0.0002130235,0.00006699837,0.0000286398,0.00006797924,0.00003962392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001015399,0.0002163902,0.003656573,0.0003756686,0.0001466949,0.0002113138,0.00002133203,0.01106911,0.9708203,0.001428257,0.0002734567,0.01076542],"study_design_scores_gemma":[0.00004944712,0.0006622675,0.001177064,0.000006357288,0.0001264184,0.0001286767,0.00002277004,0.02916241,0.9653721,0.0002046848,0.003073341,0.00001426433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9377217,0.003806299,0.05071039,0.0004174959,0.0001531337,0.00008946769,0.0005675548,0.0003149497,0.006218939],"genre_scores_gemma":[0.990873,0.0009031714,0.006875302,0.00003743131,0.00001360953,0.000008710758,0.0003253567,0.00002323587,0.0009402744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352471,"threshold_uncertainty_score":0.00452441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362341398881336,"score_gpt":0.2635790952667205,"score_spread":0.2499556812779071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}