{"id":"W2014711973","doi":"10.1038/sj.cgt.7700685","title":"Carcinoembryonic antigen-immunoglobulin Fc fusion protein (CEA-Fc) for identification and activation of anti-CEA immunoglobulin-T-cell receptor-modified T cells, representative of a new class of Ig fusion proteins","year":2004,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Carcinoembryonic antigen; Fusion protein; Antibody; Molecular biology; Fc receptor; Chemistry; Antigen; Monoclonal antibody; Fragment crystallizable region; Chimeric antigen receptor; Immunoglobulin G; Receptor; T cell; Immune system; Biology; Recombinant DNA; Immunology; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006656023,0.0003372834,0.0008203504,0.0002999161,0.0001177676,0.00002054933,0.0002922663,0.0002549761,0.0003946086],"category_scores_gemma":[0.00005342704,0.0003107593,0.0002460269,0.0006950698,0.0002693805,0.0001733771,0.00008159094,0.0002654259,0.00000330312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760433,"about_ca_system_score_gemma":0.001127689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003574369,"about_ca_topic_score_gemma":0.00003721614,"domain_scores_codex":[0.9970641,0.0001641572,0.001015219,0.000646205,0.0007152508,0.0003951093],"domain_scores_gemma":[0.9971073,0.00007449961,0.0009451232,0.0008809948,0.0008521048,0.0001399468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01202636,0.000639793,0.0007179864,0.0005936934,0.0002160165,8.866796e-7,0.003492833,0.0005029624,0.9638987,0.00002180869,0.0002109854,0.01767797],"study_design_scores_gemma":[0.01211739,0.00238812,0.008125192,0.0005337271,0.00004592234,0.000002987225,0.0006973917,0.0001689098,0.974728,0.0002129446,0.000741113,0.0002382592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831669,0.005636324,0.003502378,0.0005709408,0.0001732862,0.006683653,0.0001435762,0.00003509728,0.00008778158],"genre_scores_gemma":[0.9821364,0.01316774,0.002200135,0.00003429564,0.000153938,0.0003132628,0.0001953527,0.00008389418,0.001714998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01743971,"threshold_uncertainty_score":0.9999344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04396300363128967,"score_gpt":0.3274272862154109,"score_spread":0.2834642825841212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}