{"id":"W2014711973","doi":"10.1038/sj.cgt.7700685","title":"Carcinoembryonic antigen-immunoglobulin Fc fusion protein (CEA-Fc) for identification and activation of anti-CEA immunoglobulin-T-cell receptor-modified T cells, representative of a new class of Ig fusion proteins","year":2004,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Carcinoembryonic antigen; Fusion protein; Antibody; Molecular biology; Fc receptor; Chemistry; Antigen; Monoclonal antibody; Fragment crystallizable region; Chimeric antigen receptor; Immunoglobulin G; Receptor; T cell; Immune system; Biology; Recombinant DNA; Immunology; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902895,0.0003466896,0.0002508269,0.0005352716,0.0002419644,0.0003317334,0.0002860498,0.0005879242,0.001288984],"category_scores_gemma":[0.0001713933,0.0001151165,0.0002695208,0.0002832818,0.0003097559,0.0002847964,0.0003142554,0.0008224651,0.0003922586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004618671,"about_ca_system_score_gemma":0.000297182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006155719,"about_ca_topic_score_gemma":0.001193556,"domain_scores_codex":[0.9998065,0.00003047399,0.000007677724,0.00003699534,0.00007089059,0.00004759151],"domain_scores_gemma":[0.9999447,0.00001564643,0.000007993131,0.000007494907,0.000009153146,0.00001500876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008865097,0.00005261752,0.0001529076,0.00004188143,0.00000770644,0.0001101589,0.00002354755,0.0001054173,0.9916631,0.001510698,0.0002787379,0.005964561],"study_design_scores_gemma":[0.00002886926,0.000348978,0.001058041,0.000005591169,0.00002766904,0.0009402469,0.0000158978,0.0021706,0.9824069,0.0002382573,0.01275099,0.000008001681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8530071,0.02128631,0.1064451,0.0009591717,0.0003273851,0.0005309997,0.0004817077,0.0005453152,0.01641672],"genre_scores_gemma":[0.9436768,0.005337334,0.04162684,0.0002950178,0.00007816053,0.0001661749,0.0008857352,0.00003786277,0.007896189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288984,"threshold_uncertainty_score":0.004312098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04396300363128967,"score_gpt":0.3274272862154109,"score_spread":0.2834642825841212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}