{"id":"W2014721903","doi":"10.1152/ajpendo.00057.2013","title":"Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production","year":2013,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Thermogenin; Skeletal muscle; Mitochondrion; Brown adipose tissue; Internal medicine; Mitochondrial ROS; Endocrinology; Glutathione; Adipose tissue; Oxidative phosphorylation; Thermogenesis; Biology; Chemistry; Reactive oxygen species; Uncoupling protein; Bioenergetics; Cell biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422844,0.0003275225,0.0003351175,0.0001632077,0.0001522021,0.0002500823,0.0002247783,0.0002694044,0.001211819],"category_scores_gemma":[0.0001149585,0.0001317663,0.0002481172,0.0001572577,0.0002416416,0.000232569,0.0003207649,0.0006857449,0.0001805954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218721,"about_ca_system_score_gemma":0.0001747112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004128701,"about_ca_topic_score_gemma":0.001377645,"domain_scores_codex":[0.9999174,0.00001373338,0.000008001599,0.00002785603,0.00001751507,0.00001546725],"domain_scores_gemma":[0.9999189,0.00001165373,0.00003170849,0.00001077458,0.000009438494,0.00001746953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279081,0.00001881719,0.0001665445,0.00006808538,0.000007924038,0.00001903486,0.000008400511,0.00006455422,0.9975231,0.00005560535,0.00002923087,0.001910712],"study_design_scores_gemma":[0.00002522447,0.0005982904,0.007594906,0.00001973171,0.00003551502,0.0001174469,0.00003672173,0.0007334639,0.988694,0.00008530335,0.002054462,0.000004983785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915062,0.002793503,0.004368899,0.0002928814,0.00003928716,0.00002356932,0.0002290436,0.0001013282,0.000645308],"genre_scores_gemma":[0.9880091,0.002527707,0.006195262,0.0001352132,0.00001657754,0.00005137997,0.0005508837,0.00003804184,0.002475702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211819,"threshold_uncertainty_score":0.00405395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276427618417182,"score_gpt":0.2442772522840794,"score_spread":0.2315129760999076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}