{"id":"W2014731361","doi":"10.1002/hep.22877","title":"Variants in interferon‐alpha pathway genes and response to pegylated interferon‐Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long‐term treatment against cirrhosis trial†‡","year":2009,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Saint Louis University; National Cancer Institute; National Institutes of Health; Virginia Commonwealth University; New England Research Institutes; Valeant Pharmaceuticals International; University of Colorado School of Medicine, Anschutz Medical Campus; University of Connecticut; University of Southern California; University of Washington; Massachusetts General Hospital","keywords":"Ribavirin; Medicine; Pegylated interferon; Odds ratio; Hepatitis C virus; Internal medicine; Hepatitis C; Alpha interferon; Interferon; Immunology; Cirrhosis; Virology; Gastroenterology; Interferon alfa; ITPA; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007769689,0.0005137332,0.001386381,0.001057643,0.0001066204,0.00004625453,0.0001934979,0.0003591984,0.00004787611],"category_scores_gemma":[0.0002791772,0.0003993757,0.000223449,0.0006852226,0.0001868248,0.0001694752,0.00006333802,0.0001863771,0.00002500039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002857284,"about_ca_system_score_gemma":0.0007184765,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02454109,"about_ca_topic_score_gemma":0.1552906,"domain_scores_codex":[0.9956684,0.001270594,0.001094486,0.0008063566,0.0003085848,0.0008515702],"domain_scores_gemma":[0.9981058,0.000669039,0.0002068618,0.0006876035,0.000135587,0.0001951298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05459176,0.002155328,0.6278487,0.00007742304,0.0001453338,0.0007861371,0.002937236,0.000007492927,0.01995829,0.00003014358,0.00003647147,0.2914256],"study_design_scores_gemma":[0.06314252,0.08271003,0.8210639,0.000388741,0.0001314026,0.0001216419,0.0000324971,0.003866201,0.02623889,0.00005108306,0.001795543,0.0004575771],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917283,0.001116714,0.0002858103,0.001160527,0.0002821399,0.005038343,0.0001776688,0.00005326837,0.0001572017],"genre_scores_gemma":[0.9819248,0.01610645,0.0001099111,0.0002729825,0.00012265,0.001130952,0.0001572008,0.00005030543,0.0001247865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.290968,"threshold_uncertainty_score":0.9998458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04882496986236118,"score_gpt":0.3535325032776403,"score_spread":0.3047075334152791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}