{"id":"W2014740457","doi":"10.1016/s0003-2697(03)00193-3","title":"Frontal affinity chromatography–mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor","year":2003,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Muscular Dystrophy Canada","funders":"","keywords":"Chemistry; Chromatography; Mass spectrometry; Ligand (biochemistry); Dissociation constant; Affinity chromatography; Receptor; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003133356,0.0005216457,0.0009876257,0.0003500222,0.0001450613,0.00003792878,0.0006970777,0.0006156168,0.000395457],"category_scores_gemma":[0.0006755332,0.0005148365,0.001033538,0.002004699,0.001447756,0.0001094161,0.00008663299,0.0004399201,0.000004256856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005570686,"about_ca_system_score_gemma":0.0001670328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001569997,"about_ca_topic_score_gemma":0.000003305446,"domain_scores_codex":[0.9968753,0.00002707678,0.001042451,0.0008756868,0.000483265,0.0006961622],"domain_scores_gemma":[0.997106,0.0006341142,0.0005179037,0.001172655,0.0002823727,0.0002869625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006682532,0.0008753253,0.07629426,0.00173768,0.0006689988,0.00000496859,0.00001181311,0.000002304463,0.9119396,0.008003258,0.0003422171,0.00005278154],"study_design_scores_gemma":[0.001184163,0.00004207519,0.0001581964,0.0001299424,0.0003940547,0.0000193249,0.0008197117,0.000159499,0.9922209,0.003505587,0.0008518247,0.0005146925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756535,0.001092383,0.009108476,0.000114102,0.00002468131,0.0002803385,0.001124763,0.0001941495,0.01240757],"genre_scores_gemma":[0.9925521,0.00007670261,0.006405993,0.00001495944,0.00007279616,0.000132764,0.0002024027,0.00005291944,0.0004893787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08028136,"threshold_uncertainty_score":0.9997303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00641973142755641,"score_gpt":0.2341366906555045,"score_spread":0.2277169592279481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}